Results 71 to 80 of about 1,094,070 (306)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Oswald Schmiedeberg - the "father" of experimental pharmacology [PDF]

, 2017
Oswald Schmiedeberg (1838-1921) was a son of a bailiff and a maid of honour, the eldest of the six children in the family. He was born and educated in the Russian Empire. Scientific activity.
Zakharova, E. V., Pokrovskii, M. V., Avtina, T. V.   +2 more
core   +2 more sources

Nouvelles applications des insaponifiables et des lipides de synthèse d’origine végétale en dermocosmétique

Oléagineux, Corps gras, Lipides, 2004
Lipid chemistry is the main know-how of the research and development Center of Laboratoires Expanscience. Our paper will be focused on this field with special emphasize on three different techniques molecular distillation, bio-enzymatic reaction and ...
Piccardi Nathalie, Broutin Nicole, Garnier Sébastien, Legrand Jacques, Choulot Jean-Christophe, Chadoutaud Bernard, Msika Philippe   +6 more
doaj   +1 more source

The Hedyotis diffusa Willd. (Rubiaceae): A Review on Phytochemistry, Pharmacology, Quality Control and Pharmacokinetics

Molecules, 2016
Hedyotis diffusa Willd (H. diffusa) is a well-known Chinese medicine with a variety of activities, especially its anti-cancer effect in the clinic. Up to now, 171 compounds have been reported from H.
Rui Chen, Jingyu He, Xueli Tong, Lan Tang, Menghua Liu   +4 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

A Comprehensive Review of the Phytochemistry and Therapeutic Efficacy of Viola yedoensis Makino

Molecules
Viola yedoensis Makino (V. yedoensis), a perennial herb in the Violaceae family, is recognized for its violet flowers and has a longstanding role in ethnomedicine for treating various inflammatory diseases, such as boils, furuncles, carbuncles, and both ...
Shuang Wang, Congcong Shen, Shengyu Zhang, Han Di, Yanhong Wang, Feng Guan   +5 more
doaj   +1 more source

Inactivation of the Medial-Prefrontal Cortex Impairs Interval Timing Precision, but Not Timing Accuracy or Scalar Timing in a Peak-Interval Procedure in Rats

Frontiers in Integrative Neuroscience, 2018
Motor sequence learning, planning and execution of goal-directed behaviors, and decision making rely on accurate time estimation and production of durations in the seconds-to-minutes range. The pathways involved in planning and execution of goal-directed
Catalin V. Buhusi, Catalin V. Buhusi, Marcelo B. Reyes, Cody-Aaron Gathers, Sorinel A. Oprisan, Mona Buhusi, Mona Buhusi   +6 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

In vitro systems to study nephropharmacology: 2D versus 3D models [PDF]

, 2016
The conventional 2-dimensional (2D) cell culture is an invaluable tool in, amongst others, cell biology and experimental pharmacology. However, cells cultured in 2D, on the top of stiff plastic plates lose their phenotypical characteristics and fail in ...
Sanchez-Romero, N., Masereeuw, R., Sub Experimental pharmacology, Schophuizen, Carolien M S, Masereeuw, Rosalinde, Schophuizen, C.M., Sánchez-Romero, Natalia, Pharmacology, Gimenez, I., Sub General Pharmacology, Giménez, Ignacio   +10 more
core   +2 more sources

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source