Results 101 to 110 of about 6,306 (210)

Context Engineering for AI‐Assisted Pharmacometrics: A Practical Tutorial

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 8, August 2026.
ABSTRACT Large language models can execute pharmacometric workflows, but they make consequential domain‐specific errors when task instructions lack adequate details. This tutorial teaches pharmacometricians how to define self‐contained tasks that embed domain‐specific rules, verification criteria, and worked examples into each step of a pharmacometric ...
Ari Pritchard‐Bell, Chih‐Wei Lin, William Holmes, Sameer Doshi   +3 more
wiley   +1 more source

A Systematic Review of Published Physiologically Based Pharmacokinetic Models for Drug Excretion Into Human Breastmilk: Knowledge Gaps and Opportunities to Optimize Reporting and Modeling Practices

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 8, August 2026.
ABSTRACT Physiologically based pharmacokinetic (PBPK) modeling is increasingly used to predict infant exposure to medications via breast milk. Existing guidance on reporting of PBPK modeling analyses is unstructured and nonbinding to researchers. We evaluated reporting practices and modeling approaches in published PBPK modeling studies.
Joshua Kiptoo, Davies Otieno, Kenta Yoshida, Neel Deferm, Aida Nakayiwa Kawuma, Francis Williams Ojara, Adeniyi Olagunju, Jackson K. Mukonzo, Catriona Waitt   +8 more
wiley   +1 more source

Lithium Dispensing Patterns in Dutch Youth: Prevalence, Incidence Dosages, and Duration of Use From 2011 to 2022

Bipolar Disorders, Volume 28, Issue 5, August 2026.
ABSTRACT Objective Bipolar disorder (BD) often emerges during mid‐adolescence and young adulthood, and leads to functional and social impairment, with a prevalence of 0.87% among Dutch youth. Lithium, the first‐line BD maintenance treatment, stabilizes mood, prevents suicide, and is well tolerated, yet its use has declined as long‐term second ...
Ravish N. Gangapersad, Lisa T. Ringeling, Jens H. J. Bos, Birgit C. P. Koch, Manon H. J. Hillegers, Pilar Garcia‐Gomez, Catharina C. M. Schuiling‐Veninga, Eelko Hak, Bram Dierckx   +8 more
wiley   +1 more source

Pharmacometrics and/or Systems Pharmacology [PDF]

CPT: Pharmacometrics & Systems Pharmacology, 2019
openaire   +3 more sources

A Simulation‐Based Assessment of Dosage Regimen Appropriateness for Multiple Myeloma Medicines Reflecting Demographic and Ethnic Differences

Clinical and Translational Science, Volume 19, Issue 8, August 2026.
ABSTRACT Bridging studies are often waived for orphan diseases such as multiple myeloma (MM) due to challenges in conducting clinical trials in small and heterogeneous populations. However, demographic and regional differences between trial participants and Asian populations may influence drug exposure and response.
Minji Kang, Suein Choi, Sung‐Soo Park, Sungpil Han, Seunghoon Han   +4 more
wiley   +1 more source

Data‐driven disease progression model of Parkinson's disease and effect of sex and genetic variants

CPT: Pharmacometrics & Systems Pharmacology
As Parkinson's disease (PD) progresses, there are multiple biomarker changes, and sex and genetic variants may influence the rate of progression. Data‐driven, long‐term disease progression model analysis may provide precise knowledge of the relationships
Ryota Jin, Hideki Yoshioka, Hiromi Sato, Akihiro Hisaka   +3 more
doaj   +1 more source

Tutorial on Analyzing Patient‐Reported Outcome Measures in Clinical Development

Clinical and Translational Science, Volume 19, Issue 8, August 2026.
ABSTRACT Patient‐reported outcomes (PROs) are now considered essential components of clinical development and regulatory assessment. Despite their widespread collection, PRO data remain under‐utilized, with analyses often limited to descriptive summaries or single time‐point comparisons that fail to capture the richness, longitudinal structure, and ...
Krina Mehta, Jim H. Hughes, Jiawei Zhou, Benyam Muluneh, Ari Gnanasakthy   +4 more
wiley   +1 more source

Deep‐Learning: An Emerging Tool to Support Model‐Informed Drug Development

Clinical and Translational Science, Volume 19, Issue 8, August 2026.
ABSTRACT Traditional Model‐Informed Drug Development (MIDD) primarily relies on hypothesis‐driven (HD) models based on biological, physiological, and physicochemical principles. While these mechanistic models have been instrumental in drug development and regulatory decision‐making, they may be limited in capturing complex nonlinear relationships. Deep
Roberto Gomeni, Françoise Bressolle‐Gomeni   +1 more
wiley   +1 more source

Population Pharmacokinetic and Exposure‐Response Analyses of Ibrutinib Combined With Bendamustine and Rituximab in Patients With Mantle Cell Lymphoma

CPT: Pharmacometrics & Systems Pharmacology
Efficacy and safety of ibrutinib 560 mg once daily or placebo combined with bendamustine and rituximab (BR) were assessed in patients with mantle cell lymphoma in a randomized phase 3 study (SHINE).
Per Olsson Gisleskog, Belén Valenzuela, Nicoline Treijtel, Sanjay Deshpande, Todd Henninger, Juan José Perez‐Ruixo   +5 more
doaj   +1 more source

Applying a Pharmacometrics‐Enabled Machine Learning Analysis to Predict 2‐Month Culture Conversion Using Phase 2a Data in a Tuberculosis Clinical Trial

Clinical and Translational Science, Volume 19, Issue 8, August 2026.
A workflow for appying pharmacometrics‐enable machine learning analysis to predict 2‐month culture conversion using phase 2a data. ABSTRACT Phase 2a trials in tuberculosis patients traditionally assess early bactericidal activity over two weeks, often using the time‐to‐positivity biomarker, followed by a phase 2b study typically lasting 8‐week with ...
Huifang You, Ulrika S. H. Simonsson
wiley   +1 more source