Results 191 to 200 of about 11,033 (240)
Risk Assessment for Drug-Induced Hyperbilirubinemia: A Mechanistic Approach. [PDF]
CPT Pharmacometrics Syst PharmacolKumar R +4 more
europepmc +1 more source
Mathematical Modeling of the Role of Cytokines in Sindbis Virus Treatment of Glioblastoma. [PDF]
CPT Pharmacometrics Syst PharmacolMakam S, Dobrovolny HM.
europepmc +1 more source
Development of a Pregnancy-Specific Physiologically Based Pharmacokinetics (PBPK) Model for Aspirin. [PDF]
CPT Pharmacometrics Syst PharmacolCollins-Smith A +5 more
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Population Pharmacokinetic/Pharmacodynamic Modeling of Donidalorsen, an Antisense Oligonucleotide in Development for Prophylaxis of Hereditary Angioedema. [PDF]
CPT Pharmacometrics Syst PharmacolDiep JK +7 more
europepmc +1 more source
Pharmacometrics in tuberculosis: progress and opportunities [PDF]
International Journal of Antimicrobial Agents, 2022 Tuberculosis (TB) remains one of the leading causes of death by a communicable agent, infecting up to one-quarter of the world's population, predominantly in disadvantaged communities. Pharmacometrics employ quantitative mathematical models to describe the relationships between pharmacokinetics and pharmacodynamics, and to predict drug doses, exposures
Justin J Wilkins +2 more
exaly +4 more sources
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The Relevance of Epigenetics and Epigenomics to Pharmacometrics
Epigenomics, 2023Jacob Peedicayil +1 more
exaly +3 more sources
Therapeutic Innovation & Regulatory Science, 2019
Pharmacometrics have advanced from compartmental analysis to noncompartmental analysis and population pharmacokinetics that require complicated mathematical programs. These sophisticated mathematical analyses determine not only the usual pharmacometric measures of clearance and volume of distribution but also the effects of covariates on these measures.
Xiaoxi Liu, Robert M. Ward
openaire +2 more sources
Pharmacometrics have advanced from compartmental analysis to noncompartmental analysis and population pharmacokinetics that require complicated mathematical programs. These sophisticated mathematical analyses determine not only the usual pharmacometric measures of clearance and volume of distribution but also the effects of covariates on these measures.
Xiaoxi Liu, Robert M. Ward
openaire +2 more sources
The Journal of Clinical Pharmacology, 2010
This special issue of the Journal of Clinical Pharmacology is dedicated to pharmacometrics, covering topics related to methodological research, application to decisions, standardization, PhRMA survey, and growth strategy. Innovative methodological and technological advances in analyzing disease, drug, and trial data have equipped pharmacometricians ...
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This special issue of the Journal of Clinical Pharmacology is dedicated to pharmacometrics, covering topics related to methodological research, application to decisions, standardization, PhRMA survey, and growth strategy. Innovative methodological and technological advances in analyzing disease, drug, and trial data have equipped pharmacometricians ...
openaire +2 more sources
Pharmacometrics in Pain Management
The Biomedical & Life Sciences Collection, 2014© American Association of Pharmaceutical Scientists 2014 S. Schmidt, H. Derendorf (eds.), Applied Pharmacometrics, AAPS Advances in the Pharmaceutical Sciences Series 14, DOI 10.1007/978-1-4939-1304-6_18 Y. Wang () · P. Ji · J. Liu · H. Zhu Office of Clinical Pharmacology, Center for Drug Evaluation and Research, US Food and Drug Administration, 10903
Yaning Wang, Jiang Liu, Hao Zhu, Ping Ji
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Pharmacometrics in Pregnancy: An Unmet Need
Annual Review of Pharmacology and Toxicology, 2014Pregnant women and their fetuses are orphan populations with respect to the safety and efficacy of drugs. Physiological and absorption, distribution, metabolism, and excretion (ADME) changes during pregnancy can significantly affect drug pharmacokinetics (PK) and may necessitate dose adjustment.
Ke, Alice Ban +3 more
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