Results 201 to 210 of about 11,033 (240)

Pharmacometrics and Systems Pharmacology 2030

Clinical Pharmacology & Therapeutics, 2019
In 2012, a new journal was launched from the ASCPT family, CPT: Pharmacometrics and Systems Pharmacology (PSP) as both quantitative system pharmacology (QSP) and pharmacometrics were growing fields in pharmacology, drug development, and drug use. In this Perspective, the present editors and associate editors of PSP want to share their strategic vision ...
France, Mentré, Lena E, Friberg, Stephen, Duffull, Jonathan, French, Douglas A, Lauffenburger, Lang, Li, Donald E, Mager, Vikram, Sinha, Eric, Sobie, Ping, Zhao   +9 more
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Pharmacometrics of Hyperlipidemia

2014
Arteriosclerosis of the coronary and peripheral vasculature is the undisputed leading cause of death worldwide resulting from cardiovascular disease, peripheral vascular disease, and stroke. Lipoproteins represent a surrogate for one of the significant cardiovascular risk factors, and mathematical models to understand lipoprotein kinetics have been ...
Maurice G. Emery, Peter C. Haughney, John P. Gibbs   +2 more
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Clinical pharmacometrics

2021
Στις μέρες μας, η μαθηματική μοντελοποίηση έχει αποδειχθεί ότι αποτελεί ένα πολύ σημαντικό στοιχείο της κλινικής φαρμακευτικής. Στην παρούσα διατριβή, τεχνικές πληθυσμιακής μοντελοποίησης, παλινδρόμησης, προσομοίωσης και μηχανικής μάθησης εφαρμόστηκαν για την βελτιστοποίηση δoσολογικών σχημάτων, για να διερευνηθεί η επίδραση της γαστρικής κένωσης και ...
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Pharmacometrics in Dermatology

2014
There is increasing recognition of the impact of pharmacometrics in improving drug development and influencing regulatory decision making across different therapeutic areas. However, the field of dermatology remains largely underserved by pharmacometrics with limited number of examples illustrating the application of modeling and simulation methods in ...
Vivek S. Purohit, Manisha Lamba, Pankaj Gupta   +2 more
openaire   +1 more source

Pharmacometrics and Tuberculosis

2014
There are very few effective tuberculosis (TB) drugs available, and for active disease, they must be used in combinations of four or more drugs and for many months. Treatment guidelines are very helpful, and include considerable empiric evidence.
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Applications of pharmacometrics in drug development

Advanced Drug Delivery Reviews
The last two decades have witnessed profound changes in how advanced computational tools can help leverage tons of data to improve our knowledge, and ultimately reduce cost and increase productivity in drug development. Pharmacometrics has demonstrated its impact through model-informed drug development (MIDD) approaches.
Yuan Xiong, Mahesh N. Samtani, Daniele Ouellet   +2 more
exaly   +3 more sources

Pharmacometrics in Pediatrics

2014
Pharmacometric approaches applied to the design and analysis of pediatric clinical pharmacology trials are essential for providing informative dosing guidance in children. This chapter reviews the key questions that define the proper implementation of pharmacometrics in the study of pediatric populations, examines historical, current, and optimal ...
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Pharmacometrics of Viral Infections

2014
Antiviral drugs play a crucial role in the treatment of human infections caused by viral pathogens. In order for antiviral therapy to be efficacious, the optimal dose and dosing interval for each compound must be identified. Optimal dosage regimens are defined as regimens that maximize inhibition of viral replication, prevent the emergence of ...
George L. Drusano, Ashley N. Brown
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Pharmacometrics in Bacterial Infections

2014
Pharmacometrics plays an important role in rational dosing design of antimicrobial therapy by defining the relationship between dose, dosing interval, drug concentration, bacterial response, infection outcome, and toxicity, as well as the variability surrounding these variables.
Sherwin K. B. Sy, Hartmut Derendorf
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Defining the Future of Pharmacometrics: The American Society of Pharmacometrics

The Journal of Clinical Pharmacology, 2010
Marc, Pfister, Richard C, Brundage, Marc R, Gastonguay, Raymond, Miller, Stacey J, Tannenbaum, David Z, D'Argenio   +5 more
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