Results 11 to 20 of about 140,892 (150)

Estimation of healthcare‐related charges in women with BRCA mutations and breast cancer

BMC Health Services Research, 2021
Background Breast cancer costs were estimated at $16.5 billion in 2010 and were higher than other cancer costs. There are limited studies on breast cancer charges and costs by BRCA mutations and receptor status. We examined overall health care and breast
Joseph Biskupiak, Sudhir Unni, Claire Telford, Minkyoung Yoo, Xiangyang Ye, Rishi Deka, Diana Brixner, David Stenehjem   +7 more
doaj   +1 more source

Dasatinib reverses drug resistance by downregulating MDR1 and Survivin in Burkitt lymphoma cells

BMC Complementary Medicine and Therapies, 2020
Background Current chemotherapies for Burkitt lymphoma (BL) have dramatically improved its clinical outcome. However, chemoresistance can lead to chemotherapy failure and very poor prognosis; thus, novel strategies are urgently required for patients with
Mitsuki Tabata, Masanobu Tsubaki, Tomoya Takeda, Keisuke Tateishi, Katsumasa Tsurushima, Motohiro Imano, Takao Satou, Toshihiko Ishizaka, Shozo Nishida   +8 more
doaj   +1 more source

Activation of Serum/Glucocorticoid Regulated Kinase 1/Nuclear Factor-κB Pathway Are Correlated with Low Sensitivity to Bortezomib and Ixazomib in Resistant Multiple Myeloma Cells

Biomedicines, 2021
Multiple myeloma (MM) is an incurable malignancy often associated with primary and acquired resistance to therapeutic agents, such as proteasome inhibitors.
Masanobu Tsubaki, Tomoya Takeda, Takuya Matsuda, Shiori Seki, Yoshika Tomonari, Shoutaro Koizumi, Miki Nagatakiya, Mai Katsuyama, Yuuta Yamamoto, Katsumasa Tsurushima, Toshihiko Ishizaka, Shozo Nishida   +11 more
doaj   +1 more source

Regulation of gap junctions by nitric oxide influences the generation of arrhythmias resulting from acute ischemia and reperfusion in vivo.

Frontiers in Pharmacology, 2013
Myocardial ischemia resulting from sudden occlusion of a coronary artery is one of the major causes in the appearance of severe, often life-threatening ventricular arrhythmias.
Ágnes eVégh, Gönczi eMárton, Miskolczi eGottfried, Kovács eMária   +3 more
doaj   +1 more source

The Nonsteroidal Anti-Inflammatory Drug Ketorolac Alters the Small Intestinal Microbiota and Bile Acids Without Inducing Intestinal Damage or Delaying Peristalsis in the Rat

Frontiers in Pharmacology, 2021
Background: Nonsteroidal anti-inflammatory drugs (NSAIDs) induce significant damage to the small intestine, which is accompanied by changes in intestinal bacteria (dysbiosis) and bile acids.
Barbara Hutka, Bernadette Lázár, András S. Tóth, Bence Ágg, Bence Ágg, Szilvia B. László, Nóra Makra, Balázs Ligeti, Bálint Scheich, Kornél Király, Mahmoud Al-Khrasani, Dóra Szabó, Péter Ferdinandy, Péter Ferdinandy, Klára Gyires, Zoltán S. Zádori   +15 more
doaj   +1 more source

In vitro evaluation of antioxidant and neuroprotective effects of curcumin loaded in Pluronic micelles

Biotechnology & Biotechnological Equipment, 2016
Curcumin is a polyphenolic substance with attractive pharmacological activities (e.g. antioxidant, anti-inflammatory, anticancer). Incorporation of curcumin in polymeric micelles could overcome the problems associated with its instability and low aqueous
Cvetelina Gorinova, Denitsa Aluani, Yordan Yordanov, Magdalena Kondeva-Burdina, Virginia Tzankova, Cvetelina Popova, Krassimira Yoncheva   +6 more
doaj   +1 more source

Cardiac electrophysiological remodeling associated with enhanced arrhythmia susceptibility in a canine model of elite exercise

eLife, 2023
The health benefits of regular physical exercise are well known. Even so, there is increasing evidence that the exercise regimes of elite athletes can evoke cardiac arrhythmias including ventricular fibrillation and even sudden cardiac death (SCD).
Alexandra Polyák, Leila Topal, Noémi Zombori-Tóth, Noémi Tóth, János Prorok, Zsófia Kohajda, Szilvia Déri, Vivien Demeter-Haludka, Péter Hegyi, Viktória Venglovecz, Gergely Ágoston, Zoltán Husti, Péter Gazdag, Jozefina Szlovák, Tamás Árpádffy-Lovas, Muhammad Naveed, Annamária Sarusi, Norbert Jost, László Virág, Norbert Nagy, István Baczkó, Attila S Farkas, András Varró   +22 more
doaj   +1 more source

Opioids, Polypharmacy, and Drug Interactions: A Technological Paradigm Shift Is Needed to Ameliorate the Ongoing Opioid Epidemic

Pharmacy, 2020
Polypharmacy is a common phenomenon among adults using opioids, which may influence the frequency, severity, and complexity of drug–drug interactions (DDIs) experienced.
Adriana Matos, David L. Bankes, Kevin T. Bain, Tyler Ballinghoff, Jacques Turgeon   +4 more
doaj   +1 more source

Adverse drug event risk assessment by the virtual addition of COVID‐19 repurposed drugs to Medicare and commercially insured patients’ drug regimens: A drug safety simulation study

Clinical and Translational Science, 2021
Drug safety is generally established from clinical trials, by pharmacovigilance programs and during observational phase IV safety studies according to drug intended or approved indications.
Matt K. Smith, Ravil Bikmetov, Sweilem B. Al Rihani, Malavika Deodhar, Matthew Hafermann, Pamela Dow, Jacques Turgeon, Veronique Michaud   +7 more
doaj   +1 more source

The effect of a long-term treatment with cannabidiol-rich hemp extract oil on the adenosinergic system of the zucker diabetic fatty (ZDF) rat atrium

Frontiers in Pharmacology, 2022
Cannabidiol (CBD), the most extensively studied non-intoxicating phytocannabinoid, has been attracting a lot of interest worldwide owing to its numerous beneficial effects.
Gabor Viczjan, Gabor Viczjan, Anna Szilagyi, Barbara Takacs, Ignac Ovari, Reka Szekeres, Vera Tarjanyi, Tamas Erdei, Vanda Teleki, Judit Zsuga, Zoltan Szilvassy, Bela Juhasz, Balazs Varga, Rudolf Gesztelyi   +13 more
doaj   +1 more source