Results 21 to 30 of about 131,053 (266)

Cardiac electrophysiological remodeling associated with enhanced arrhythmia susceptibility in a canine model of elite exercise

eLife, 2023
The health benefits of regular physical exercise are well known. Even so, there is increasing evidence that the exercise regimes of elite athletes can evoke cardiac arrhythmias including ventricular fibrillation and even sudden cardiac death (SCD).
Alexandra Polyák, Leila Topal, Noémi Zombori-Tóth, Noémi Tóth, János Prorok, Zsófia Kohajda, Szilvia Déri, Vivien Demeter-Haludka, Péter Hegyi, Viktória Venglovecz, Gergely Ágoston, Zoltán Husti, Péter Gazdag, Jozefina Szlovák, Tamás Árpádffy-Lovas, Muhammad Naveed, Annamária Sarusi, Norbert Jost, László Virág, Norbert Nagy, István Baczkó, Attila S Farkas, András Varró   +22 more
doaj   +1 more source

Opioids, Polypharmacy, and Drug Interactions: A Technological Paradigm Shift Is Needed to Ameliorate the Ongoing Opioid Epidemic

Pharmacy, 2020
Polypharmacy is a common phenomenon among adults using opioids, which may influence the frequency, severity, and complexity of drug–drug interactions (DDIs) experienced.
Adriana Matos, David L. Bankes, Kevin T. Bain, Tyler Ballinghoff, Jacques Turgeon   +4 more
doaj   +1 more source

Adverse drug event risk assessment by the virtual addition of COVID‐19 repurposed drugs to Medicare and commercially insured patients’ drug regimens: A drug safety simulation study

Clinical and Translational Science, 2021
Drug safety is generally established from clinical trials, by pharmacovigilance programs and during observational phase IV safety studies according to drug intended or approved indications.
Matt K. Smith, Ravil Bikmetov, Sweilem B. Al Rihani, Malavika Deodhar, Matthew Hafermann, Pamela Dow, Jacques Turgeon, Veronique Michaud   +7 more
doaj   +1 more source

Treatment of Type 1 and Type 2 Diabetes Mellitus with Insulin Detemir, a Long-Acting Insulin Analog

Clinical Medicine Insights: Endocrinology and Diabetes, 2010
Insulin detemir is a long-acting basal insulin approved for use in patients with type 1 (T1DM) or type 2 diabetes (T2DM). Insulin detemir has demonstrated equivalent glycemic control and hypoglycemic risk when compared to insulin glargine, and insulin ...
Jason R. Young, Carrie Mcadam-Marx
doaj   +1 more source

Rehabilitation pharmacotherapy: A combination of rehabilitation and pharmacotherapy

Journal of General and Family Medicine, 2018
Sarcopenia, malnutrition, and polypharmacy are major causes of frailty in older people. Some frail older people become disabled through stroke, pneumonia, hip fracture, and other diseases. Sarcopenia, malnutrition, and polypharmacy tend to worsen disability in older people.
openaire   +2 more sources

Mechanisms of CYP450 Inhibition: Understanding Drug-Drug Interactions Due to Mechanism-Based Inhibition in Clinical Practice

Pharmaceutics, 2020
In an ageing society, polypharmacy has become a major public health and economic issue. Overuse of medications, especially in patients with chronic diseases, carries major health risks. One common consequence of polypharmacy is the increased emergence of
Malavika Deodhar, Sweilem B Al Rihani, Meghan J. Arwood, Lucy Darakjian, Pamela Dow, Jacques Turgeon, Veronique Michaud   +6 more
doaj   +1 more source

Electroencephalographic Normalization as a Biomarker of Clinical Recovery in Down Syndrome Regression Disorder

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Down syndrome regression disorder is a syndrome characterized by subacute loss of cognitive, behavioral, and functional abilities in individuals with Down syndrome. Electroencephalography abnormalities are frequently observed during evaluation, but it remains unclear whether these findings represent a dynamic marker of disease ...
Jonathan D. Santoro, Mackenzie Silverman, Maeve C. Lucas, Mariam M. Yousuf, Samuel T. Otey, Stella V. Gray, Brittany Jordan, Madeline D. Kahan, Latanya D. Agurs, Michelle Van Hirtum Das, Deborah Holder, Devin King, Eileen A. Quinn, Ryan Kammeyer, Michael S. Rafii   +14 more
wiley   +1 more source

Safety and Efficacy of GLP‐1 Receptor Agonists in Adults With Epilepsy, Obesity, and Type 2 Diabetes

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Managing obesity in patients with epilepsy is complicated by the weight‐gaining properties of essential antiseizure medications (ASMs) such as valproate and pregabalin. We evaluated the safety and efficacy of initiating glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) in this population.
Hyoshin Son, Inyoung Hwang, Sang Won Lee, Yun Kim   +3 more
wiley   +1 more source

Information needs of physicians regarding the diagnosis of rare diseases: a questionnaire-based study in Belgium

Orphanet Journal of Rare Diseases, 2019
Background Late and misdiagnoses of rare disease patients are common and often result in medical, physical and mental burden for the patient, and financial and emotional burden for the patient’s family.
Liese Vandeborne, Eline van Overbeeke, Marc Dooms, Birgit De Beleyr, Isabelle Huys   +4 more
doaj   +1 more source

Hemokinin-1 is a mediator of chronic restraint stress-induced pain

Scientific Reports, 2023
The Tac4 gene-derived hemokinin-1 (HK-1) binds to the NK1 receptor, similarly to Substance P, and plays a role in acute stress reactions and pain transmission in mice.
Éva Borbély, Angéla Kecskés, József Kun, Eszter Kepe, Barbara Fülöp, Katalin Kovács-Rozmer, Bálint Scheich, Éva Renner, Miklós Palkovits, Zsuzsanna Helyes   +9 more
doaj   +1 more source