Results 21 to 30 of about 140,892 (150)

Treatment of Type 1 and Type 2 Diabetes Mellitus with Insulin Detemir, a Long-Acting Insulin Analog

Clinical Medicine Insights: Endocrinology and Diabetes, 2010
Insulin detemir is a long-acting basal insulin approved for use in patients with type 1 (T1DM) or type 2 diabetes (T2DM). Insulin detemir has demonstrated equivalent glycemic control and hypoglycemic risk when compared to insulin glargine, and insulin ...
Jason R. Young, Carrie Mcadam-Marx
doaj   +1 more source

Information needs of physicians regarding the diagnosis of rare diseases: a questionnaire-based study in Belgium

Orphanet Journal of Rare Diseases, 2019
Background Late and misdiagnoses of rare disease patients are common and often result in medical, physical and mental burden for the patient, and financial and emotional burden for the patient’s family.
Liese Vandeborne, Eline van Overbeeke, Marc Dooms, Birgit De Beleyr, Isabelle Huys   +4 more
doaj   +1 more source

Mechanisms of CYP450 Inhibition: Understanding Drug-Drug Interactions Due to Mechanism-Based Inhibition in Clinical Practice

Pharmaceutics, 2020
In an ageing society, polypharmacy has become a major public health and economic issue. Overuse of medications, especially in patients with chronic diseases, carries major health risks. One common consequence of polypharmacy is the increased emergence of
Malavika Deodhar, Sweilem B Al Rihani, Meghan J. Arwood, Lucy Darakjian, Pamela Dow, Jacques Turgeon, Veronique Michaud   +6 more
doaj   +1 more source

Hemokinin-1 is a mediator of chronic restraint stress-induced pain

Scientific Reports, 2023
The Tac4 gene-derived hemokinin-1 (HK-1) binds to the NK1 receptor, similarly to Substance P, and plays a role in acute stress reactions and pain transmission in mice.
Éva Borbély, Angéla Kecskés, József Kun, Eszter Kepe, Barbara Fülöp, Katalin Kovács-Rozmer, Bálint Scheich, Éva Renner, Miklós Palkovits, Zsuzsanna Helyes   +9 more
doaj   +1 more source

Applicability of drug-related problem (DRP) classification system for classifying severe medication errors

BMC Health Services Research, 2023
Background Several classification systems for medication errors (MEs) have been established over time, but none of them apply optimally for classifying severe MEs.
Carita Linden-Lahti, Anna Takala, Anna-Riia Holmström, Marja Airaksinen   +3 more
doaj   +1 more source

Risk Assessment of Drug‐Induced Long QT Syndrome for Some COVID‐19 Repurposed Drugs

Clinical and Translational Science, 2021
The risk‐benefit ratio associated with the use of repurposed drugs to treat severe acute respiratory syndrome‐coronavirus 2 (SARS‐CoV‐2)‐related infectious coronavirus disease 2019 (COVID‐19) is complicated because benefits are awaited, not proven.
Veronique Michaud, Pamela Dow, Sweilem B. Al Rihani, Malavika Deodhar, Meghan Arwood, Brian Cicali, Jacques Turgeon   +6 more
doaj   +1 more source

Tirzepatide, a dual GIP/GLP1-receptor co-agonist preserves cardiac function and improves survival in angiotensin II-induced heart failure model in mice: comparison to liraglutide

Cardiovascular Diabetology
Background Incretin analogues, used for the treatment of type 2 diabetes mellitus and obesity, such as GLP1-receptor agonist liraglutide (Lira) have been shown to reduce major adverse cardiac events in recent clinical trials of heart failure. Tirzepatide
Zsombor I. Hegedűs, Márk E. Jakab, Tamás G. Gergely, Nabil V. Sayour, Andrea Kovács, Sára Antal, Tamás Kovács, Péter Ferdinandy, Zoltán V. Varga, Viktória E. Tóth   +9 more
doaj   +1 more source

Flurbiprofen ameliorated obesity by attenuating leptin resistance induced by endoplasmic reticulum stress

EMBO Molecular Medicine, 2014
Endoplasmic reticulum (ER) stress, caused by the accumulation of unfolded proteins, is involved in the development of obesity. We demonstrated that flurbiprofen, a nonsteroidal anti‐inflammatory drug (NSAID), exhibited chaperone activity, which reduced ...
Toru Hosoi, Rie Yamaguchi, Kikuko Noji, Suguru Matsuo, Sachiko Baba, Keisuke Toyoda, Takahiro Suezawa, Takaaki Kayano, Shinpei Tanaka, Koichiro Ozawa   +9 more
doaj   +1 more source

Antidepressant use during pregnancy and the risk of developing gestational hypertension: a retrospective cohort study

BMC Pregnancy and Childbirth, 2018
Background Prior studies reported that exposure to antidepressants during pregnancy may be associated with gestational hypertension. The aim of this study is to assess the association between the use of antidepressants during pregnancy and the risk of ...
Neily Zakiyah, Loes F. ter Heijne, Jens H. Bos, Eelko Hak, Maarten J. Postma, Catharina C. M. Schuiling-Veninga   +5 more
doaj   +1 more source

The Influence of Cannabidiol on the Pharmacokinetics of Methylphenidate in Healthy Subjects

Medical Cannabis and Cannabinoids, 2022
Introduction: Cannabidiol (CBD) is a widely utilized nonpsychoactive cannabinoid available as an over-the-counter supplement, a component of medical cannabis, and a prescriptive treatment of childhood epilepsies.
John S. Markowitz, Ludmila De Faria, Qingchen Zhang, Philip W. Melchert, Reginald F. Frye, Brandon O. Klee, Yuli Qian   +6 more
doaj   +1 more source