Results 31 to 40 of about 301,634 (281)

Adverse drug event risk assessment by the virtual addition of COVID‐19 repurposed drugs to Medicare and commercially insured patients’ drug regimens: A drug safety simulation study

Clinical and Translational Science, 2021
Drug safety is generally established from clinical trials, by pharmacovigilance programs and during observational phase IV safety studies according to drug intended or approved indications.
Matt K. Smith, Ravil Bikmetov, Sweilem B. Al Rihani, Malavika Deodhar, Matthew Hafermann, Pamela Dow, Jacques Turgeon, Veronique Michaud   +7 more
doaj   +1 more source

Cardiac electrophysiological remodeling associated with enhanced arrhythmia susceptibility in a canine model of elite exercise

eLife, 2023
The health benefits of regular physical exercise are well known. Even so, there is increasing evidence that the exercise regimes of elite athletes can evoke cardiac arrhythmias including ventricular fibrillation and even sudden cardiac death (SCD).
Alexandra Polyák, Leila Topal, Noémi Zombori-Tóth, Noémi Tóth, János Prorok, Zsófia Kohajda, Szilvia Déri, Vivien Demeter-Haludka, Péter Hegyi, Viktória Venglovecz, Gergely Ágoston, Zoltán Husti, Péter Gazdag, Jozefina Szlovák, Tamás Árpádffy-Lovas, Muhammad Naveed, Annamária Sarusi, Norbert Jost, László Virág, Norbert Nagy, István Baczkó, Attila S Farkas, András Varró   +22 more
doaj   +1 more source

Potentially inappropriate prescribing in nursing home residents detected with the community pharmacist specific GheOP3S-tool [PDF]

, 2016
Background: The Ghent Older People’s Prescriptions community Pharmacy Screening (GheOP3S-)tool was recently developed to screen for potentially inappropriate prescribing (PIP).
Boussery, Koen, Mattelin, Kristof, Mehuys, Els, PATTYN, EVA, Petrovic, Mirko, Somers, Annemie, Tommelein, Eline, Van Damme, Charlotte   +7 more
core   +1 more source

Opioids, Polypharmacy, and Drug Interactions: A Technological Paradigm Shift Is Needed to Ameliorate the Ongoing Opioid Epidemic

Pharmacy, 2020
Polypharmacy is a common phenomenon among adults using opioids, which may influence the frequency, severity, and complexity of drug–drug interactions (DDIs) experienced.
Adriana Matos, David L. Bankes, Kevin T. Bain, Tyler Ballinghoff, Jacques Turgeon   +4 more
doaj   +1 more source

Breathing SPACE – a practical approach to the breathless patient. [PDF]

, 2016
Breathlessness is a common symptom which may have multiple causes in any one individual and causes which may change over time. Breathlessness campaigns encourage people to see their GP if they are unduly breathless.
Baxter, N, Hopkinson, NS
core   +1 more source

Treatment of Type 1 and Type 2 Diabetes Mellitus with Insulin Detemir, a Long-Acting Insulin Analog

Clinical Medicine Insights: Endocrinology and Diabetes, 2010
Insulin detemir is a long-acting basal insulin approved for use in patients with type 1 (T1DM) or type 2 diabetes (T2DM). Insulin detemir has demonstrated equivalent glycemic control and hypoglycemic risk when compared to insulin glargine, and insulin ...
Jason R. Young, Carrie Mcadam-Marx
doaj   +1 more source

Mechanisms of CYP450 Inhibition: Understanding Drug-Drug Interactions Due to Mechanism-Based Inhibition in Clinical Practice

Pharmaceutics, 2020
In an ageing society, polypharmacy has become a major public health and economic issue. Overuse of medications, especially in patients with chronic diseases, carries major health risks. One common consequence of polypharmacy is the increased emergence of
Malavika Deodhar, Sweilem B Al Rihani, Meghan J. Arwood, Lucy Darakjian, Pamela Dow, Jacques Turgeon, Veronique Michaud   +6 more
doaj   +1 more source

Hemokinin-1 is a mediator of chronic restraint stress-induced pain

Scientific Reports, 2023
The Tac4 gene-derived hemokinin-1 (HK-1) binds to the NK1 receptor, similarly to Substance P, and plays a role in acute stress reactions and pain transmission in mice.
Éva Borbély, Angéla Kecskés, József Kun, Eszter Kepe, Barbara Fülöp, Katalin Kovács-Rozmer, Bálint Scheich, Éva Renner, Miklós Palkovits, Zsuzsanna Helyes   +9 more
doaj   +1 more source

Neural correlates of outcome of the psychotherapy compared to antidepressant therapy in anxiety and depression disorders: a meta-analysis [PDF]

, 2017
The most prevalent mental disorders, anxiety and depression, are commonly associated with structural and functional changes in the fronto-limbic brain areas.
Aceto, Paola, Altavilla, Daniela, Di Giorgio, Chiara, Kalsi, Navkiran, Lai, Carlo, Tambelli, Renata, Trentini, Cristina   +6 more
core   +3 more sources

The effect of a long-term treatment with cannabidiol-rich hemp extract oil on the adenosinergic system of the zucker diabetic fatty (ZDF) rat atrium

Frontiers in Pharmacology, 2022
Cannabidiol (CBD), the most extensively studied non-intoxicating phytocannabinoid, has been attracting a lot of interest worldwide owing to its numerous beneficial effects.
Gabor Viczjan, Gabor Viczjan, Anna Szilagyi, Barbara Takacs, Ignac Ovari, Reka Szekeres, Vera Tarjanyi, Tamas Erdei, Vanda Teleki, Judit Zsuga, Zoltan Szilvassy, Bela Juhasz, Balazs Varga, Rudolf Gesztelyi   +13 more
doaj   +1 more source