Results 101 to 110 of about 1,067,694 (318)

In silico and in vitro exploration of a tyrosinase for biocatalytic production of catechols

FEBS Open Bio, EarlyView.
Tyrosinase from Ralstonia pseudosolanacearum is a promising biocatalyst for producing valuable catechols from monophenol substrates. This tyrosinase is uniquely suited to this due to its high monophenolase : diphenolase ratio. We combined in silico docking and in vivo kinetic characterisation of this tyrosinase with 11 industrially relevant monophenols,
James Britton, Fang Zhao, Reeta Davis, Meg Walsh, Kevin E O'Connor, David O'Connell, Tanja Narancic   +6 more
wiley   +1 more source

Expert consensus on the preparation and use of temporarily compounded eye drops for eye infectious diseases

Yanke Xuebao
Commercial eye drops fail to fully meet the therapeutic requirements for infectious ocular diseases. When treating certain infectious ocular diseases where existing ophthalmic preparations are inadequate, extemporaneously prepared eye drops become ...
Ophthalmic Pharmacy Expert Committee of Guangdong Pharmaceutical Association
doaj   +1 more source

Five‐Year Outcomes of Laparoscopic Sphincter‐Preserving Surgery for Rectal Cancer: A Prospective Study in Elderly Vietnamese Patients

Aging and Cancer, EarlyView.
This prospective study demonstrates that laparoscopic sphincter‐preserving surgery is feasible for elderly patients. While overall survival reaches 70% at 5 years, advanced T‐stage and the omission of neoadjuvant therapy significantly drive recurrence, highlighting the need for personalized geriatric protocols despite logistical challenges.
Huu Duc Ho, Quang Le, Ngoc Thach Tran, Van Viet Ung, Loc Vu   +4 more
wiley   +1 more source

Characteristics and Efficacy of Warfarin Sodium Tablet Subdivided by 3D Printing Technology: A Retrospective Cohort Study of Patients After Prosthetic Valve Replacement

Drug Design, Development and Therapy
Jieqiong Lv,1 Kaixia Fu,2 Lingjuan Xiong,3 Bishan Chen,4 Luchuan Zhan,3 Jiang Liu,3 Zhanyi Lin,5 Fan Yang,2,4 Jisheng Chen4 1Department of Pharmacy, The Second Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, People’s ...
Lv J, Fu K, Xiong L, Chen B, Zhan L, Liu J, Lin Z, Yang F, Chen J   +8 more
doaj  

Structure–Function Decoupling of the Sensorimotor and Default Mode Networks in Black Americans With MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Multiple sclerosis (MS) exhibits racially disparate rates of disease progression. Black people with MS (B‐PwMS) experience a more severe disease course than non‐Hispanic White people with MS (NHW‐PwMS). Here we investigated structural and functional connectivity as well as structure–function decoupling in the ...
Emilio Cipriano, Giacomo Boffa, Maria Petracca, Marta Ponzano, Nicole Graziano, Claire Wigley, Claire Riley, Jonathan Howard, Pietro Bontempi, Sylvia Klineova, Fred Lublin, Matilde Inglese   +11 more
wiley   +1 more source

The Pathophysiological Role of Mitochondrial Oxidative Stress in Rheumatic Diseases

Journal of Inflammation Research
Zhao Ma,1 Qiaoping Xu,2,* Xinchang Xu1,* 1Department of Pharmacy, Hangzhou Third People’s Hospital, Hangzhou Third Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, 310009, People’s Republic of China; 2Department of ...
Ma Z, Xu Q, Xu X
doaj  

Validity of a Wearable Digital Insole for Assessing Gait ON and OFF in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Gait impairment is a distinctive symptom of Parkinson's disease that negatively impact mobility. We assessed the validity of wearable digital insoles against a validated reference gait analysis system for measuring select gait characteristics in patients with Parkinson's disease. Methods A comparative analysis between digital insoles
Deborah A. Hall, Kimberly Kwei, Rolando J. Acosta, Bharatkumar Koyani, Erin Robertson, Pratyush Rai, Roland Barge, Emily Timm, Nicollette L. Purcell, Natasha Desai, Dhanesh Patel, Ana‐Maria Visoiu‐Knapp, Samuel Stuart, Rinol Alaj, Matthew F. Wipperman, Oren Levy, Joan A. O'Keefe   +16 more
wiley   +1 more source

Rapid Health Evaluation of Analgesia with Long-Acting Local Anesthesia After Hip and Knee Arthroplasty

Integrated Pharmacy Research and Practice
Xiaoyue Zhang, Mengting Li, Luwen Lei Department of Pharmacy, Department of The Sixth Affiliated Hospital, School of Medicine, South China University of Technology, Foshan, People’s Republic of ChinaCorrespondence: Luwen Lei, Email leiluwen618@163 ...
Zhang X, Li M, Lei L
doaj  

Epilepsy‐Associated Variants of a Single SCN1A Codon Exhibit Divergent Functional Properties

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Pathogenic variants in SCN1A, which encodes the voltage‐gated sodium channel NaV1.1, are associated with multiple epilepsy syndromes exhibiting a range of clinical severity. SCN1A variants are reported in different syndromes, including Dravet syndrome, which is associated with loss‐of‐function, whereas neonatal/infantile‐onset ...
Lanie N. Liebovitz, Christopher H. Thompson, Linda C. Laux, Alfred L. George Jr.   +3 more
wiley   +1 more source

Real-World Pharmacokinetic and Exposure–Response Characterization of Venetoclax in Chinese Patients with Hematological Malignancies

Drug Design, Development and Therapy
Zhirui Liu,1,* Xin Liu,2,* Qiang Gong,3,* Shiwei Qin,1 Xiao Zhu,2,4 Isabelle Hui-San Kuan,5 Wen Yao Mak,2 Xiaoqiang Xiang,2 Changsheng Jia,1 Qian Wang,1 Lin Cheng,1 Ling Li6,7 1Department of Pharmacy, the First Affiliated Hospital
Liu Z, Liu X, Gong Q, Qin S, Zhu X, Kuan IHS, Mak WY, Xiang X, Jia C, Wang Q, Cheng L, Li L   +11 more
doaj