Results 81 to 90 of about 1,067,694 (318)
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Navigating the Wild West of Medication Adherence Reporting in Specialty Pharmacy.
Journal of Managed Care & Specialty Pharmacy, 2019 Estimating medication adherence through the use of pharmacy claims-based adherence calculations such as medication possession ratio (MPR) and proportion of days covered (PDC) plays a significant role in specialty pharmacy practice.
Scott L Canfield +8 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
Competence: the categorical apparatus of higher pharmaceutical education
Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2017 Despite the institutional importance of the law on higher education legal category of “qualification”, as a result of a formal assessment and recognition of education, it should be also noted that in its articulation of the Law of Ukraine “On higher ...
I. M. Alyeksyeyeva
doaj +1 more source
FEBS Open Bio, EarlyView.This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake +4 more
wiley +1 more source
Towards a Greater Professional Standing: Evolution of Pharmacy Practice and Education, 1920–2020
Pharmacy, 2019 The history of community pharmacy in America since the 1920s is one of slow progress towards greater professional standing through changes in pharmacy education and practice.
B. Urick, Emily V Meggs
semanticscholar +1 more source
FEBS Open Bio, EarlyView.Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young +7 more
wiley +1 more source
Significant Predictors of Azithromycin in Population Pharmacokinetic Analysis: A Systematic Review
Drug Design, Development and TherapyRuncong Zhang,1,2,* Yuebin Fang,3,* Yinhui Wang,1,2 Jing Fan,1,2 Weiming Yin,1,2 Weibin Fan,1,2 Yuetian Yu,2,4,5 Bin Lin1,2,4 1Department of Pharmacy, Changxing People’s Hospital, Changxing, Zhejiang, People’s Republic of China; 2Key ...
Zhang R +7 more
doaj
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source