Results 21 to 30 of about 84,518 (238)

A New Antimalarial Noreudesmane Sesquiterpenoid from Dobinea delavayi

Natural Products and Bioprospecting, 2020
One previously undescribed angeloylated noreudesmane sesquiterpenoid, dobinin O (1), along with four known eudesmane sesquiterpenoids (2–5) were isolated from the peeled roots of Dobinea delavayi.
Xiu-Rong Wu, Yi Shen, Shu-Jun Cui, Xiao-Lei Luo, Chao-Jiang Xiao, Bei Jiang   +5 more
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Exploring the effect of Yinzhihuang granules on alcoholic liver disease based on pharmacodynamics, network pharmacology and molecular docking

Chinese Medicine, 2023
Background Yinzhihuang granules (YZHG) is a commonly used Chinese patent medicine for the treatment of liver disease. However, the mechanism of YZHG in alcoholic liver disease (ALD) is still unclear. Methods This study combined liquid chromatography-mass
Yingying Tan, Fanqin Zhang, Xiaotian Fan, Shan Lu, Yingying Liu, Zhishan Wu, Zhihong Huang, Chao Wu, Guoliang Cheng, Bing Li, Jiaqi Huang, Antony Stalin, Wei Zhou, Jiarui Wu   +13 more
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Study on Formulation, in vivo Exposure, and Passive Targeting of Intravenous Itraconazole Nanosuspensions

Frontiers in Pharmacology, 2019
The pharmacokinetic profile of a drug can be different when delivered as a nanosuspension compared with a true solution, which may in turn affect the therapeutic effect of the drug.
Qi Yuan, Yanling Wang, Rufeng Song, Xianqiao Hou, Keke Yu, Jiaojiao Zheng, Juanmei Zhang, Xiaohui Pu, Jihong Han, Lanlan Zong   +9 more
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Siwei Jianbu decoction improves painful paclitaxel-induced peripheral neuropathy in mouse model by modulating the NF-κB and MAPK signaling pathways

Regenerative Medicine Research, 2020
Background: Paclitaxel, a commonly used chemotherapeutic agent, is usually associated with peripheral neuropathy. Paclitaxel induced peripheral neuropathy (PIPN) can be dose limiting and may have detrimental influence on patients' quality of life ...
Suo Jinshuai, Wang Man, Zhang Peng, Lu Yuting, Xu Rong, Zhang Ling, Qiu Siyan, Zhang Qiuyan, Qian Yangyan, Meng Jing, Zhu Jing   +10 more
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Bufalin-Loaded PEGylated Liposomes: Antitumor Efficacy, Acute Toxicity, and Tissue Distribution

Nanoscale Research Letters, 2019
Bufalin, derived from Venenum Bufonis, exerts antitumor effects but has low bioavailability and adverse effects when administered as a single agent.
Jiani Yuan, Cheng Zeng, Wei Cao, Xuanxuan Zhou, Yang Pan, Yanhua Xie, Yifang Zhang, Qian Yang, Siwang Wang   +8 more
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Tanshinone IIA attenuates the stemness of breast cancer cells via targeting the miR-125b/STARD13 axis

Experimental Hematology & Oncology, 2022
Background Tanshinone II A is an effective component extracted from Salvia miltiorrhiza and the roles of Tanshinone IIA in regulating the stemness of tumor cells remain unclear.
Xiaoman Li, Qi Jia, Yinyin Zhou, Xuan Jiang, Li Song, Yuanyuan Wu, Aiyun Wang, Wenxing Chen, Shijun Wang, Yin Lu   +9 more
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MATERIA MEDICA AND PHARMACY

The American Journal of the Medical Sciences, 1906
Mode of access: Internet.
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GCIP attenuates DOCA/salt-induced cardiac hypertrophy and fibrosis in mice

Di-san junyi daxue xuebao, 2022
Objective To determine the effects of improvement of G alpha q-protein carboxyl terminus imitation polypeptide (GCIP) on deoxycorticosterone acetate (DOCA)/salt-induced cardiac hypertrophy and fibrosis in mice.
TANG Kecheng, LIU Qiao, YANG Shengqian, ZHONG Bin, LUO Qingman, LI Xiaohui   +5 more
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Identification of key pharmacological components and targets for Aidi injection in the treatment of pancreatic cancer by UPLC-MS, network pharmacology, and in vivo experiments

Chinese Medicine, 2023
Background Pancreatic cancer is one of the most lethal cancers worldwide. Aidi injection (ADI) is a representative antitumor medication based on Chinese herbal injection, but its antitumor mechanisms are still poorly understood.
Haojia Wang, Zhishan Wu, Xiaotian Fan, Chao Wu, Shan Lu, Libo Geng, Antony Stalin, Yingli Zhu, Fanqin Zhang, Jiaqi Huang, Pengyun Liu, Huiying Li, Leiming You, Jiarui Wu   +13 more
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Crosstalks between mTORC1 and mTORC2 variagate cytokine signaling to control NK maturation and effector function

Nature Communications, 2018
The metabolic regulator protein family, mTOR, regulate natural killer (NK) cell development and function, but the underlying mechanism is unclear. Here, the authors show that Raptor/mTORC1 and Rictor/mTORC2 form a feedback crosstalk network to variegate ...
Fangjie Wang, Meng Meng, Banghui Mo, Yao Yang, Yan Ji, Pei Huang, Wenjing Lai, Xiaodong Pan, Tingting You, Hongqin Luo, Xiao Guan, Yafei Deng, Shunzong Yuan, Jianhong Chu, Michael Namaka, Tiffany Hughes, Lilin Ye, Jianhua Yu, Xiaohui Li, Youcai Deng   +19 more
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