Results 41 to 50 of about 88,549 (174)

A novel function of NLRP3 independent of inflammasome as a key transcription factor of IL-33 in epithelial cells of atopic dermatitis

Cell Death and Disease, 2021
Atopic dermatitis (AD) is a common chronic pruritic inflammatory skin disorder characterized by recurrent eczematous lesions. Interleukin (IL)−33, a cytokine of the IL-1 family, was found to play an important role in the pathogenesis of AD.
Jie Zheng, Lu Yao, Yijing Zhou, Xiaoqun Gu, Can Wang, Kaifan Bao, Yang Sun, Min Hong   +7 more
doaj   +1 more source

Based on Systematic Pharmacology: Molecular Mechanism of Siwei Jianbu Decoction in Preventing Oxaliplatin-Induced Peripheral Neuropathy

Neural Plasticity, 2020
Chemotherapy-induced peripheral neuropathy (CIPN) is a dose-limiting side effect caused by chemotherapy drugs, and its existence seriously affects the quality of life of patients.
Peng Zhang, Yuting Lu, Chao Yang, Qiuyan Zhang, Yangyan Qian, Jinshuai Suo, Peng Cheng, Jing Zhu   +7 more
doaj   +1 more source

A novel biomimetic liposome drug delivery system mediated by macrophage targeting for precision treatment of encephalitis

BMEMat, EarlyView.
An advanced macrophage‐mediated biomimetic liposome (AC‐LP@RAW) that can penetrate the BBB and precisely target inflammatory sites in the deep brain was established in this study based on the unique immune homing property of macrophages, and showed a significantly improved delivery of curcumin to the brain.
Mengru Wu, Baoqin Song, Zhihao Chen, Wenzhong Li, Wanjun Liang, Xiu Wang   +5 more
wiley   +1 more source

Controllable engineered probiotic microspheres for treating ulcerative colitis: A cascade enzyme‐catalyzed strategy to restore intestinal redox homeostasis

BMEMat, EarlyView.
A dual strategy integrating genetic engineering and physical encapsulation was proposed to enhance the cell viability and antioxidant properties of probiotics. The cascade antioxidant enzymes released from probiotic microspheres restore intestinal redox homeostasis by eliminating intestinal reactive oxygen species for ulcerative colitis treatment ...
Xiaolong Mao, Xiangwei Lv, Miaomiao Zhang, Jiayi Liu, Yun Chen, Yunna Li, Gaoyuan Liu, Fuming Yang, Ziqiang Han, Yunyun Wei   +9 more
wiley   +1 more source

SAFEGUARDING CHINESE MATERIA MEDICA: ONE FAMILY AS A CASE OF TRANSMITTING TRANS-REGIONAL PHARMA-CRAFT, AND SCHOLARLY SCIENCE IN CONTEMPORARY CHINA [PDF]

, 2016
Chinese medicine is a faceted field, both multi-disciplinary in academia, and multi-occupational in the praxis and education of medical treatments. Basic tasks that specialised personnel need to solve include the supply of medicinal drugs and materials ...
Springer, Lena
core   +1 more source

Astragaloside IV accelerates hematopoietic reconstruction by improving the AMPK/PGC1α-mediated mitochondrial function in hematopoietic stem cells

Chinese Medicine
Background Radiotherapy can damage hematopoietic stem cells (HSC) in bone marrow, leading to impaired hematopoietic function. Current treatments mainly target differentiated hematopoietic progenitor cells, which may accelerate their depletion ...
Ling Zhang, Wanqi Xu, Yueying Zeng, Long Wang, Jiesi Luo, Xiaogang Zhou, Qibing Mei, Dalian Qin, Anguo Wu, Jianming Wu, Feihong Huang   +10 more
doaj   +1 more source

Membrane‐Permeable Nucleoside T‐1106 Diphosphate and Triphosphate Analogues as Antiviral Pronucleotides

Chemistry – A European Journal, EarlyView.
Favipiravir (T‐705) and the non‐fluorinated counterpart (T‐1106) are antiviral agents that inhibit the RNA‐dependent RNA polymerase (RdRp) of various RNA viruses. The antiviral efficacy of nucleoside analogues is strongly dependent on their intracellular activation by cellular kinases to produce their corresponding triphosphate metabolites (T‐705‐RTP ...
Chris Meier, Duan Li, Leentje Persoons, Graciela Andrei, Robert Snoeck, Dominique Schols, Lieve Naesens, Xiao Jia   +7 more
wiley   +1 more source

Enhancing Optogenetics‐Based Cancer Therapy Via Nanotechnology

Exploration, EarlyView.
Nanotechnology enhances optogenetics‐based cancer therapy through improved delivery systems and non‐invasive optical regulation. It further enables precise and programmable control of optogenetic living therapeutics for localized antitumor responses.
Honggang Shen, Wenzhe Yi, Rongzhang Li, Shuangshuang Hu, Xindi Qian, Dan Yan, Qian Zou, Guanru Wang, Yaping Li   +8 more
wiley   +1 more source

Materia medica in 18th century Jesuit pharmacies. Between tradition and innovation

, 2018
Przemiany w farmacji wczesnonowożytnej i ich recepcja w kręgu aptekarstwa jezuickiego -- Surowce pochodzenia roślinnego -- Surowce pochodzenia mineralnego -- Surowce pochodzenia zwierzęcego -- Gotowe leki.Reikšminiai žodžiai: Abiejų Tautų Respublika (ATR;
Mariani, Andrea
core   +1 more source

Recent advances of NFATc1 in rheumatoid arthritis-related bone destruction: mechanisms and potential therapeutic targets

Molecular Medicine
Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease characterized by inflammation of the synovial tissue and joint bone destruction, often leading to significant disability.
Hao Zheng, Yuexuan Liu, Yasi Deng, Yunzhe Li, Shiqi Liu, Yong Yang, Yun Qiu, Bin Li, Wenbing Sheng, Jinzhi Liu, Caiyun Peng, Wei Wang, Huanghe Yu   +12 more
doaj   +1 more source