Results 51 to 60 of about 94,243 (174)

AS‐TLC‐Based High‐Throughput Screening Integrated with CuAAC Optimization Strategy Facilitates the Rapid Discovery of YTHDC1 Inhibitor

Advanced Science, EarlyView.
We developed Affinity Selection Thin‐Layer Chromatography (AS‐TLC) as a method for high‐throughput screening (HTS) of compound mixtures. Furthermore, we integrated activity assays with AS‐TLC and identified a YTH domain‐containing protein 1 (YTHDC1) inhibitor. Building on this hit, we applied copper(I)‐catalyzed azide–alkyne cycloaddition (CuAAC) click
Mingchen Wang, Shuiping Fu, Ye Xu, Jia Gao, Jiwei Ren, Xu Yang, Hesong Xu, Ge Sun, Yanjie Li, Yanlin Wang, Lu Jin, Peijuan Chen, Ying Xu, Jianhao Li, Hua Lin, Chujiao Hu, Kaixian Chen, Huan Xiong, Cheng Luo, Shijie Chen   +19 more
wiley   +1 more source

Materia medica in 18th century Jesuit pharmacies. Between tradition and innovation

, 2018
Przemiany w farmacji wczesnonowożytnej i ich recepcja w kręgu aptekarstwa jezuickiego -- Surowce pochodzenia roślinnego -- Surowce pochodzenia mineralnego -- Surowce pochodzenia zwierzęcego -- Gotowe leki.Reikšminiai žodžiai: Abiejų Tautų Respublika (ATR;
Mariani, Andrea
core   +1 more source

Danshen-Shanzha formula for the treatment of atherosclerosis: ethnopharmacological relevance, preparation methods, chemical constituents, pharmacokinetic properties, and pharmacological effects

Frontiers in Pharmacology
Danshen-Shanzha Formula (DSF) is a well-known herbal combination comprising Radix Salvia Miltiorrhiza (known as Danshen in Chinese) and Fructus Crataegi (known as Shanzha in Chinese), It has been documented to exhibit considerable benefits for promoting ...
Qiong Xu, Zhe Yu, Meng Zhang, Meng Zhang, Tian Feng, Fan Song, Haifeng Tang, Siwang Wang, Hua Li   +8 more
doaj   +1 more source

Inhibitory effect of phillyrin on lipopolysaccharide-induced activation of rat hepatic stellate cells in vitro

Di-san junyi daxue xuebao, 2020
Objective To investigate the inhibitory effect of phillyrin (PHI) on lipopolysaccharide (LPS)-induced hepatic stellate cell (HSC) activation and explore the possible mechanisms. Methods Cultured rat hepatic stellate cells (HSC-T6) were divided into blank
LI Jiahang, YANG Shengqian, YANG Shengqian, LIU Juanjuan, LUO Mingming, CHEN Jie, LI Xiaohui   +6 more
doaj   +1 more source

Uhrf1‐Mediated PKM2 Degradation via Ubiquitination Alleviates Inflammation and Pyroptosis in Inflammatory Bowel Disease

Advanced Science, EarlyView.
Uhrf1‐mediated PKM2 ubiquitination and degradation repressed the nuclear translocation of PKM2, and EPT served as a molecular glue capable of targeting the Uhrf1–PKM2 complex to alleviate the IBD course, suggesting that the Uhrf1–PKM2 axis was a previously unrecognized strategy for treating IBD.
Juan Zhang, Xin‐Rong Xu, Hui‐Lin Zhang, Qi‐Meng Zhu, Xin‐Yuan Li, Xi‐Peng Shang, Jing‐Hui Du, Christophe Morisseau, Feng Qiu, Cheng‐Peng Sun   +9 more
wiley   +1 more source

Near‐Infrared Fluorescent PROTAC Enables Theranostic Imaging and Selective Tau Degradation in Alzheimer's Disease

Advanced Science, EarlyView.
Here, we report a novel NIR fluorescent PROTAC platform that enables real‐time imaging and targeted degradation of Alzheimer's p‐Tau. Our lead compound effectively clears p‐Tau, reduces APP/Aβ, and alleviates cognitive deficits in AD mice. This work demonstrates a theranostic strategy for visualizing degradation and developing next‐generation AD ...
Ziwei Ren, Qian Yue, Ning Gao, Qiu‐Lian Hao, Yan Huo, Chuchu Li, Xinyue Leng, Lu‐Lu Sun, Maggie Pui Man Hoi, Hai‐Hao Han, Mingliang Ma, Xu‐Wen Li   +11 more
wiley   +1 more source

Effective extraction of Xuetongsu and its role in preventing RA synovial hyperplasia by targeting synovial cell migration and apoptosis

Scientific Reports
Kadsura heteroclita (Roxb) Craib also named Xuetong in Tujia ethnomedicine in China, has been traditionally employed in rheumatoid arthritis (RA) treatment.
Yasi Deng, Hao Zheng, Shiqi Liu, Ying Deng, Yuxin Chen, Ling Liang, Mengyun Wang, Qingling Xie, Yupei Yang, Bin Li, Juan Huang, Hanwen Yuan, Huanghe Yu, Wei Wang   +13 more
doaj   +1 more source

Cryptotanshinone inhibits PFK-mediated aerobic glycolysis by activating AMPK pathway leading to blockade of cutaneous melanoma

Chinese Medicine
Background Cutaneous melanoma is a kind of skin malignancy with low morbidity but high mortality. Cryptotanshinone (CPT), an important component of salvia miltiorrhiza has potent anti-tumor activity and also indicates therapeutic effect on dermatosis. So
Qiong Chen, Yang Liu, Yunxuan Zhu, Ziyan Zhu, Jueyao Zou, Yanhong Pan, Yin Lu, Wenxing Chen   +7 more
doaj   +1 more source

Resveratrol ameliorates atherosclerosis induced by high-fat diet and LPS in ApoE−/− mice and inhibits the activation of CD4+ T cells

Nutrition & Metabolism, 2020
Background Atherosclerosis (AS), which characterized with the accumulation of lipids on the vessel wall, is the pathological basis of many cardiovascular diseases (CVD) and seriously threatens human health.
Liyu Zhou, Jun Long, Yuting Sun, Weikai Chen, Runze Qiu, Dongping Yuan   +5 more
doaj   +1 more source

The validation of the Royal Stoke Pharmacy Workforce Calculator – a mixed methods study [PDF]

, 2018
Background The Royal Stoke Pharmacy Workforce Calculator (RSPWC) was developed to meet a local need of identifying clinical pharmacy staffing levels, not described nationally.
Bednall, Ruth
core