Results 51 to 60 of about 88,549 (174)

Efficient Synthesis of 2,3′-Spirobi (Indolin)-2′-Ones and Preliminary Evaluation of Their Damage to Mitochondria in HeLa Cells

Frontiers in Pharmacology, 2022
A novel formal (4 + 1) annulation between N-(o-chloromethyl)aryl amides and 3-chlorooxindoles through in situ generated aza-ortho-QMs with 3-chlorooxindoles is reported for the synthesis of a series of 2,3′-spirobi (indolin)-2′-ones in high yields. Under
Huajie Li, Huajie Li, Zhenjie Yu, Zhenjie Yu, Haoyi Sun, Haoyi Sun, Bo Liu, Bo Liu, Xin Wang, Xin Wang, Zhe Shao, Zhe Shao, Meiling Wang, Meiling Wang, Weilin Xie, Weilin Xie, Xingang Yao, Qingqiang Yao, Qingqiang Yao, Ying Zhi, Ying Zhi   +20 more
doaj   +1 more source

A Pharmacogenomics‐Guided Antihypertensive Strategy for Blood Pressure Reduction in Rural China: A Cluster‐Randomized Controlled Trial

Health Care Science, EarlyView.
This manuscript reports the findings from the Pharmacogenomic‐guided Antihypertensive Strategy Trial study amidst the deteriorating blood pressure control observed globally during the COVID‐19 pandemic. A pharmacogenomics‐guided strategy achieved a 98.4% blood pressure control rate at 4 weeks in rural China.
Wangjun Qin, Mengke Yu, Ying Zhu, Queran Lin, Limei Yin, Guisheng Liu, Yaping Wang, Guangqiang Lu, Xiaofei Liu, Pengmei Li, Xudong Kong, Li Zhao, Kun Tang, Jiangli Jin, Yu Xiong, Yingnan Zhao, Yan Yan, Bo Li, Azeem Majeed, Xianbo Zuo, Yue Qiu, Jiantuo Yu, Lihong Liu   +22 more
wiley   +1 more source

Danshen-Shanzha formula for the treatment of atherosclerosis: ethnopharmacological relevance, preparation methods, chemical constituents, pharmacokinetic properties, and pharmacological effects

Frontiers in Pharmacology
Danshen-Shanzha Formula (DSF) is a well-known herbal combination comprising Radix Salvia Miltiorrhiza (known as Danshen in Chinese) and Fructus Crataegi (known as Shanzha in Chinese), It has been documented to exhibit considerable benefits for promoting ...
Qiong Xu, Zhe Yu, Meng Zhang, Meng Zhang, Tian Feng, Fan Song, Haifeng Tang, Siwang Wang, Hua Li   +8 more
doaj   +1 more source

Inhibitory effect of phillyrin on lipopolysaccharide-induced activation of rat hepatic stellate cells in vitro

Di-san junyi daxue xuebao, 2020
Objective To investigate the inhibitory effect of phillyrin (PHI) on lipopolysaccharide (LPS)-induced hepatic stellate cell (HSC) activation and explore the possible mechanisms. Methods Cultured rat hepatic stellate cells (HSC-T6) were divided into blank
LI Jiahang, YANG Shengqian, YANG Shengqian, LIU Juanjuan, LUO Mingming, CHEN Jie, LI Xiaohui   +6 more
doaj   +1 more source

Hydrogel‐based drug delivery systems for intracerebral hemorrhage with therapeutic advances and emerging roles of the bone–brain axis

Interdisciplinary Medicine, EarlyView.
Hydrogel‐based drug delivery systems offer a promising approach for treating intracerebral hemorrhage (ICH) by overcoming blood‐brain barrier limitations, enabling precise, sustained release of neuroprotective and anti‐inflammatory agents. These systems enhance treatment efficacy, but challenges remain in biosafety, drug penetration, and scalability ...
Haojun Shi, Min Chen, Yisheng Chen, MengYao Li, Jiale Ma, Zuozhen Yin, Li Wu, YangBao Miao, Zemin Ou, Ke Wu, Zhijie Xu, Lizhi Li, Shaocong Zhao, Shiwei He, Bin Huang, Guanwen He, Guanghui Wu, John H. Zhang, Liang Shi   +18 more
wiley   +1 more source

Effective extraction of Xuetongsu and its role in preventing RA synovial hyperplasia by targeting synovial cell migration and apoptosis

Scientific Reports
Kadsura heteroclita (Roxb) Craib also named Xuetong in Tujia ethnomedicine in China, has been traditionally employed in rheumatoid arthritis (RA) treatment.
Yasi Deng, Hao Zheng, Shiqi Liu, Ying Deng, Yuxin Chen, Ling Liang, Mengyun Wang, Qingling Xie, Yupei Yang, Bin Li, Juan Huang, Hanwen Yuan, Huanghe Yu, Wei Wang   +13 more
doaj   +1 more source

c‐Met‐Targeted Imaging Agents: Progress and Challenges

iRADIOLOGY, EarlyView.
This review summarizes recent advances in c‐Met‐targeted imaging probes, including hepatocyte growth factor (HGF) ligands, antibodies, peptides, and small molecules across magnetic resonance imaging (MRI), positron emission tomography (PET), single‐photon emission computed tomography (SPECT), and optical imaging modalities.
Yonghao Li, Aiyan Ji, Qihang Ding, Hongyue Lou, Zhen Cheng   +4 more
wiley   +1 more source

Cryptotanshinone inhibits PFK-mediated aerobic glycolysis by activating AMPK pathway leading to blockade of cutaneous melanoma

Chinese Medicine
Background Cutaneous melanoma is a kind of skin malignancy with low morbidity but high mortality. Cryptotanshinone (CPT), an important component of salvia miltiorrhiza has potent anti-tumor activity and also indicates therapeutic effect on dermatosis. So
Qiong Chen, Yang Liu, Yunxuan Zhu, Ziyan Zhu, Jueyao Zou, Yanhong Pan, Yin Lu, Wenxing Chen   +7 more
doaj   +1 more source

Integrated phytochemical and bioactivity profiling of Xanthium strumarium fruits from Korea and China: Implications for origin‐specific quality specification

Journal of the Science of Food and Agriculture, EarlyView.
Abstract BACKGROUND Geographic origin influences the phytochemical composition and biological activities of medicinal plant resources. Xanthium strumarium L. (XS) fruit is widely used in East Asian traditional medicine. However, current pharmacopeial standards primarily recognize Chinese‐derived material, despite the availability and traditional use of
Eunsu Song, Seung‐Min Oh, Jiyeon Chun, Jinah Hwang   +3 more
wiley   +1 more source

CKLF‐like MARVEL transmembrane domain‐containing superfamily 8 (CMTM8) promotes Notch signalling to maintain CD8+ T cell‐ and NK cell‐dependent tumour immune escape

British Journal of Pharmacology, EarlyView.
Background and Purpose The CKLF‐like MARVEL transmembrane domain containing superfamily (CMTM) has an important role in tumour immunity. The role of CMTM8 in tumour immune microenvironment (TIME) remains unknown. The aim was to investigate the relationship between CMTM8 and antitumour immunity. Experimental Approach Lentiviral system was established to
Fanglin Li, Longhua Gu, Runqiu Chen, Zhiying Li, Rong Zhang, Chen Chen, Yi Liu, Xinhang Zheng, Yiting Wang, Shanna Wu, Jianhua Sun, Jing Chen, Bingshun Wang, Likun Gong, Yiru Long   +14 more
wiley   +1 more source