Results 71 to 80 of about 84,446 (125)
ABSTRACT Native to America, the pineapple—Ananas comosus (L.) Merr.—delighted the Europeans who came across it. The fruit was mentioned by the voyagers and missionaries who observed and tasted it in the Americas and, from the 1500s onwards, infused reports, chronicles and natural history treatises with colour and flavour.
Teresa Nobre de Carvalho
wiley +1 more source
THE VALUABLE CONTRIBUTIONS BY UNANI PHYSICIANS IN QARABADIN (UNANI MATERIA MEDICA) [PDF]
Qarabadin (Unani pharmacopoeias) have a rich armamentarium of natural drugs, consisting of mostly herbs but also materials of animal, mineral and marine origin.
Rasheed, H.M.A. +3 more
core +1 more source
ABSTRACT Characterising chemical and biological differences among different tissues of medicinal plants is important for understanding their tissue‐specific characteristics and medicinal efficacy. The root xylem (RX) and root bark (RB) of Tripterygium wilfordii have historically been used differently; however, the basis underlying their differential ...
Zhong Mou Zhang +5 more
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Background With extended gefitinib treatment, the therapeutic effect in some non-small cell lung cancer (NSCLC) patients declined with the development of drug resistance.
Jingyuan Zhang +15 more
doaj +1 more source
Therapeutic peptide self‐assembly is governed by multiple non‐covalent interactions, enabling the construction of diverse supramolecular structures. These self‐assembled systems can be engineered through spontaneous self‐assembly of monomers, co‐assembly, or stimulus‐responsive strategies to improve tumor delivery efficiency.
Yuelin Fang +6 more
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It is thought that polysaccharides cannot penetrate the intestinal mucosa into the circulatory system due to their high hydrophilicity and large molecular size.
Wenfeng Liao +14 more
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In this review, we provide an overview of selected historical antidotes against snakebite envenomation used in early modern Europe. Then, the evidence‐based antivenom activity of some natural compounds is discussed as resulting from more than two decades of research studies.
Elisa Bianconi +3 more
wiley +1 more source
Molecular Basis for Activation to Inhibition Switching in Kv7.2 Channel Modulators
The paper describes the serendipitous discovery of chemical manipulation allowing the activator‐to‐inhibitor switching in Kv7.2 channel modulators. The molecular determinants driving this switch have been rationalized by multidisciplinary investigation encompassing synthetic and analytical chemistry, in silico methods, cryo‐EM analysis ...
Tania Ciaglia +20 more
wiley +2 more sources
A Small‐Molecule DEPTAC Rescues Cognitive Deficits by Targeted Dephosphorylation of Pathological Tau
TP2 is a fully synthetic small‐molecule dephosphorylation‐targeting chimera that recruits endogenous PP2A‐Bα to Tau, enabling targeted removal of pathological phosphate modifications. In two tauopathy mouse models, systemic TP2 reduces Tau pathology, preserves neuronal and synaptic integrity, improves neuroimmune homeostasis, and rescues cognition ...
Fei Sun +12 more
wiley +1 more source

