Results 91 to 100 of about 94,243 (174)

TPP-related mitochondrial targeting copper (II) complex induces p53-dependent apoptosis in hepatoma cells through ROS-mediated activation of Drp1

Cell Communication and Signaling, 2019
Background In recent years, copper complexes have gradually become the focus of potential anticancer drugs due to their available redox properties and low toxicity. In this study, a novel mitochondrion-targeting copper (II) complex, [Cu (ttpy-tpp)Br2] Br
Jiangjuan Shao, Mengmeng Li, Zijian Guo, Chun Jin, Feng Zhang, Chunyan Ou, Yaochen Xie, Shanzhong Tan, Zhenyi Wang, Shizhong Zheng, Xiaoyong Wang   +10 more
doaj   +1 more source

Chemical Constituents of the Deep‐Sea‐Derived Fungus Talaromyces wortmannii and Their Ferroptosis Inhibitory Activity

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
One new tyramine derivative (1) and 28 known compounds (2–29) were isolated from deep‐sea‐derived fungus Talaromyces wortmannii. Their structures were elucidated by NMR/MS and computational calculations. Compounds 2 and 6 potently inhibited ferroptosis with EC5₀ values of 4.52 and 13.73 µM.
Ke‐Xin Ma, Zheng‐Biao Zou, Qi‐Qian Wu, Li‐Sheng Li, Ying‐Ni Pan, Xian‐Wen Yang   +5 more
wiley   +1 more source

Coix Seed Attenuates Acute Lung Injury via NLRP3 Signaling Pathway: Efficacy, Active Components, and Mechanisms

Food Science &Nutrition, Volume 14, Issue 9, September 2026.
From component identification to target validation: Coix seed extract exerts a protective effect against acute lung injury (ALI) by synergistically inhibiting inflammatory cytokines and NLRP3‐mediated pyroptosis through multiple signaling pathways. ABSTRACT Coix seed is a medicinal and nutritional resource, but its protective effects against acute lung
Qi Yan, Yuyan Li, Tingyan Chen, Wenjing Liu, Youshuo Dong, Zhangbo Ao, Hongmei Wu, Feng Xu   +7 more
wiley   +1 more source

Quelques éléments de la matière médicale arabe d'après des sceaux de verre de la première moitié du VIIIe siècle : Sami K. Hamarneh, Henry A. Awad, Arabic glass seals on early eight-century containers for materia medica. Pharmacy in History, 18, 1976, n° 3,

, 1977
Julien Pierre. Quelques éléments de la matière médicale arabe d'après des sceaux de verre de la première moitié du VIIIe siècle : Sami K. Hamarneh, Henry A. Awad, Arabic glass seals on early eight-century containers for materia medica.
Julien, Pierre
core   +1 more source

Composition of the volatile oils of the Citrus bigaradia, Citrus limon and Citrus deliciosa

Journal of Medicinal Plants, 2004
Composition of the volatile oils of the C.bigaradia, C.limon and C.delicosa have been investigated. The plant materials (leaves) were collected in spring 2000 from Corta (The medicinal plants garden) near Tonecabon, North of Iran. The oils were collected
M Mosaddegh, M Kamalinejad, A Dehmaoobad Sharifabadi, B Esfahani   +3 more
doaj  

Systematic optimization and evaluation of culture conditions for the construction of circulating tumor cell clusters using breast cancer cell lines

BMC Cancer
Background Circulating tumor cell (CTC) clusters play a critical role in carcinoma metastasis. However, the rarity of CTC clusters and the limitations of capture techniques have retarded the research progress.
Jueyao Zou, Qiong Chen, Yong He, Yanhong Pan, Han Zhao, Junfeng Shi, Zhonghong Wei, Suyun Yu, Yang Zhao, Xin Han, Yin Lu, Wenxing Chen   +11 more
doaj   +1 more source

CKLF‐like MARVEL transmembrane domain‐containing superfamily 8 (CMTM8) promotes Notch signalling to maintain CD8+ T cell‐ and NK cell‐dependent tumour immune escape

British Journal of Pharmacology, Volume 183, Issue 17, Page 5211-5229, September 2026.
Background and Purpose The CKLF‐like MARVEL transmembrane domain containing superfamily (CMTM) has an important role in tumour immunity. The role of CMTM8 in tumour immune microenvironment (TIME) remains unknown. The aim was to investigate the relationship between CMTM8 and antitumour immunity. Experimental Approach Lentiviral system was established to
Fanglin Li, Longhua Gu, Runqiu Chen, Zhiying Li, Rong Zhang, Chen Chen, Yi Liu, Xinhang Zheng, Yiting Wang, Shanna Wu, Jianhua Sun, Jing Chen, Bingshun Wang, Likun Gong, Yiru Long   +14 more
wiley   +1 more source

Integration of network pharmacology, transcriptomics and single-cell sequencing to explore the effect of Rougan Keli in alleviating liver cirrhosis

Chinese Medicine
Background The progression of liver cirrhosis leads to severe complications, significantly threatening the survival and prognosis of patients. Rou gan keli (Rgkl), a herbal formula derived from classical prescriptions, has used clinically over two ...
Chengbo Jin, Tianle Ma, Yiheng Zhang, Xujing Gu, Tong Zhu, Xinyu Wu, Xin Ding, Suzhou Huang, Yulan Wang, Zhipeng Chen, Huihua Fang, Li Wu   +11 more
doaj   +1 more source

Mechanism of Gu‐Ben‐Hua‐Shi (AESS) Formula Regulating Autophagy Through Hippo‐YAP Pathway in Restoring the Skin Barrier in Atopic Dermatitis

Journal of Cellular and Molecular Medicine, Volume 30, Issue 17, September 2026.
ABSTRACT Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by skin barrier dysfunction and immune balance disorders. Currently, drugs for repairing the skin barrier in AD are limited. The gu‐ben‐hua‐shi formula (AESS) has been shown to regulate Th1/Th2/Th17/Treg imbalance with good clinical effect.
Xin Ma, Yiting Huang, Xiao Lv, Xiumei Mo, Junfeng Liu, Fenggen Yan, Siqi Ye, Yu Zhang, Dacan Chen, Jinjing Jia   +9 more
wiley   +1 more source

TCF-1 and TOX regulate the memory formation of intestinal group 2 innate lymphoid cells in asthma

Nature Communications
Immune memory has been expanded to group 2 innate lymphoid cells (ILC2s), but the cellular and molecular bases remain incompletely understood. Based on house dust mite (HDM)-induced mice asthma models and human samples, we applied flow cytometry ...
Kaifan Bao, Xiaoqun Gu, Yajun Song, Yijing Zhou, Yanyan Chen, Xi Yu, Weiyuan Yuan, Liyun Shi, Jie Zheng, Min Hong   +9 more
doaj   +1 more source