Results 81 to 90 of about 84,446 (125)

Joseph Carson (portrait), ca. 1840-1860

1830 graduate of the University of Pennsylvania, Medical Department. Caption reads, Professor of Materia Medica and Pharmacy, University of Pennsylvania.https://jdc.jefferson.edu/historical_photos/2661/thumbnail ...

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Uhrf1‐Mediated PKM2 Degradation via Ubiquitination Alleviates Inflammation and Pyroptosis in Inflammatory Bowel Disease

Advanced Science, Volume 13, Issue 61, 3 November 2026.
Uhrf1‐mediated PKM2 ubiquitination and degradation repressed the nuclear translocation of PKM2, and EPT served as a molecular glue capable of targeting the Uhrf1–PKM2 complex to alleviate the IBD course, suggesting that the Uhrf1–PKM2 axis was a previously unrecognized strategy for treating IBD.
Juan Zhang, Xin‐Rong Xu, Hui‐Lin Zhang, Qi‐Meng Zhu, Xin‐Yuan Li, Xi‐Peng Shang, Jing‐Hui Du, Christophe Morisseau, Feng Qiu, Cheng‐Peng Sun   +9 more
wiley   +1 more source

Sister (unknown) (Hanlon) Hanlon

, 1957
entered convent in 1917; taught chemistry at the M. S. V. College and Materia Medica at the Medical School of Dalhousie University; member of the faculty of the Maritime College of Pharmacy; member of the faculty of the Maritime College of Pharmacy ...

core  

Previously Undescribed Esters and an Alkaloid From Trollius chinensis With Anti‐Inflammatory and Cytotoxic Activities

Chemistry &Biodiversity, Volume 23, Issue 11, November 2026.
Ten new compounds (9 esters, 1 alkaloid) were isolated from the flowers of Trollius chinensis Bunge, and all isolated compounds were evaluated in vitro for cytotoxicity against HeLa, HepG2, HCT 116 cells, and NO inhibition in RAW 264.7 macrophages, enriching structural diversity and providing a chemical basis for further study. . ABSTRACT In this study,
Mei‐Li Guo, Ya‐Ting Yu, Hui‐Bo Lei, Zhong‐an Mao, Rong Wang, Yu‐Jie Wang, Yong‐Fang Yuan   +6 more
wiley   +1 more source

Global Landscape and Thematic Evolution of Selective GLP‐1 Receptor Agonists and GLP‐1–Based Multi‐Receptor Agonists in Type 2 Diabetes Mellitus: A Bibliometric Analysis

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 6, November 2026.
Bibliometric analysis of 3736 publications (2004–2025) reveals rapid growth in GLP‐1–based T2DM research. The US leads, with Novo Nordisk and Eli Lilly as top contributors. Thematic shifts from glycemic control toward cardiovascular‐kidney‐metabolic outcomes and real‐world evidence, driven by landmark trials like LEADER and REWIND.
Yanbing Wang, Zhanru Liu, Shifeng Wang, Cuiyan Lv, Hesham R. El‐Seedi, Shaden A. M. Khalifa, Haiyan Wang   +6 more
wiley   +1 more source

Integrated Multi‐Omics Analysis of Polygonatum odoratum Polysaccharide in D‐Galactose‐Treated Mice Reveals Changes in Oxidative Stress Markers and Gut Microbiota

Food Science &Nutrition, Volume 14, Issue 11, November 2026.
This study evaluated the effects of Polygonatum odoratum polysaccharide (POP) in D‐galactose‐treated mice using hippocampal histology, oxidative stress measurements, and integrated multi‐omics analyses. Results showed improved hippocampal histology and oxidative stress markers, accompanied by changes in gut bacterial composition, serum metabolites, and
Wenjian Li, Yan Huang, Wenfang Zhang, Shunxiang Li, Lisong Li   +4 more
wiley   +1 more source

Identification of Candidate Biomarkers Correlated With the Pathogenesis and Prognosis of Non-small Cell Lung Cancer via Integrated Bioinformatics Analysis

Frontiers in Genetics, 2018
Background and Objective: Non-small cell lung cancer (NSCLC) accounts for 80–85% of all patients with lung cancer and 5-year relative overall survival (OS) rate is less than 20%, so that identifying novel diagnostic and prognostic biomarkers is urgently ...
Mengwei Ni, Xinkui Liu, Jiarui Wu, Dan Zhang, Jinhui Tian, Jinhui Tian, Ting Wang, Shuyu Liu, Ziqi Meng, Kaihuan Wang, Xiaojiao Duan, Wei Zhou, Xiaomeng Zhang   +12 more
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Structural Characterization and Immunomodulatory Activity of a Polysaccharide From Ipomoea batatas L. Vine: Activation of Macrophage

Food Science &Nutrition, Volume 14, Issue 11, November 2026.
IBPS‐3A, an acidic heteropolysaccharide purified from sweet potato vines, was structurally characterized to possess a backbone consisting of →4)‐α‐D‐GalpA‐(1→ and →2,4)‐α‐L‐Rhap‐(1→ linkages with arabinogalactan side chains. Further investigation revealed that IBPS‐3A induced M1 polarization in RAW264.7 macrophages, stimulating the secretion of TNF‐α ...
Yuqi Shi, Bo Si, Yu Shi, Wenxin Geng, Dunchi Xiao, Zhixiang Yuan, Liwen Li   +6 more
wiley   +1 more source

Xuetongsu attenuates bone destruction in rheumatoid arthritis by suppressing RANKL/RANK/NFATc1 pathway to inhibit osteoclastogenesis and bone resorption

Bone & Joint Research
Aims: Bone destruction is a pivotal pathological factor in the development of joint disability in rheumatoid arthritis (RA) patients, and there is a paucity of safe and effective drugs targeting bone destruction.
Hao Zheng, Yasi Deng, Bin Li, Juan Huang, Jinzhi Liu, Yupei Yang, Yuxin Chen, Linxi Mao, Yamei Li, Yuexuan Liu, Wei Wang, Huanghe Yu   +11 more
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Immunomodulatory, Antifatigue, and Hypoxia Tolerance Effects of Polygonatum cirrhifolium Polysaccharides: Structural Characterization and MAPK/NF‐κB Pathway Insights

Starch - Stärke, Volume 78, Issue 11, November 2026.
This study provides evidence that Polygonatum cirrhifolium polysaccharides possesses significant immunomodulatory, antifatigue, and hypoxia‐tolerance effects. The findings suggest that the MAPK/NF‐κB signaling pathway may be involved in its immunoregulatory actions and that PCP could be a promising candidate for enhancing physical performance and ...
Jun Nan, Yuanyuan Chen, Pei Qun, Bengui Ye, Dawa Zhuoma   +4 more
wiley   +1 more source