Results 81 to 90 of about 6,924,206 (307)

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

The Catch-22 of Pharmacy Practice in Pakistan’s Pharmacy Education

Pharmacy, 2014
New developments in the pharmacy education structure in Pakistan led to the formation of a separate department grouping high specialized services/subjects.
Atta Abbas
doaj   +1 more source

2018 Hematology/Oncology Pharmacist Association Best Practices for the Management of Oral Oncolytic Therapy: Pharmacy Practice Standard

Journal of Oncology Practice, 2019
PURPOSE: The aim of the current work was to present a pharmacy practice standard from the Hematology/Oncology Pharmacy Association (HOPA) on the management of oral oncolytic therapy.
Emily R. Mackler, E. Segal, Benyam Muluneh, K. Jeffers, J. Carmichael   +4 more
semanticscholar   +1 more source

Lipopolysaccharide uptake is augmented in lipopolysaccharide‐tolerant mouse macrophage‐like cells via increased CD14 expression

FEBS Open Bio, EarlyView.
In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara, Takayuki Manabe, Mika Jouta, Kiyoshi Kawasaki   +3 more
wiley   +1 more source

Community pharmacists' interest in and attitude to pharmacy practice research in Ethiopia: A cross-sectional study.

PLoS ONE, 2017
Pharmacy practice-research became an important component in the pharmacy practice. However, limited studies were conducted in sub-Saharan Africa to understand the pharmacists' interest and attitude towards pharmacy practice-research.
Akshaya Srikanth Bhagavathula, Eyob Alemayehu Gebreyohannes, Begashaw Melaku Gebresillassie, Daniel Asfaw Erku, Chernet Tafere Negesse, Yared Belete Belay   +5 more
doaj   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

The performance implications of pharmacy information system at the university teaching hospitals of Shiraz, Iran: Cluster approach

Journal of Advanced Pharmaceutical Technology & Research, 2017
Pharmacy information system (PIS) is becoming vital in assisting pharmacists to do their responsibilities. The aim of this study was to identify the current PIS implications in teaching hospitals affiliated with Shiraz University of Medical Science. This
Saeede Bayati, Peivand Bastani, Zahra Mahmoodzade Sagheb, Sara Jamalabadi, Mahnaz Samadbeik   +4 more
doaj   +1 more source

ASHP Practice Advancement Initiative 2030: New recommendations for advancing pharmacy practice in health systems.

American Journal of Health-System Pharmacy, 2019
PURPOSE The process of updating the recommendations of the ASHP Practice Advancement Initiative (PAI) is described, and the new recommendations targeted toward the year 2030 are presented.
Eric M. Maroyka
semanticscholar   +1 more source

The community pharmacy practice change towards patient-centered care in Saudi Arabia: a qualitative perspective

Journal of Pharmaceutical Policy and Practice, 2020
Introduction The Kingdom of Saudi Arabia (KSA) has made tremendous improvements in its health care infrastructure in a short span of time [1]. Socioeconomic changes in the KSA led to the rise of the middle-class, which means an inevitable increased ...
Muhammad Kamran Rasheed, A. Alqasoumi, S. Hasan, Z. Babar   +3 more
semanticscholar   +1 more source