Results 91 to 100 of about 311,374 (311)

Anticancer sensitivities and biological characteristics of HCT116 cells resistant to the selective poly(ADP‐ribose) glycohydrolase inhibitor

FEBS Open Bio, EarlyView.
We analyzed alterations of PAR metabolism‐related proteins in PARG inhibitor‐resistant HCT116RPDD cells. Although PARG levels remained unchanged, HCT116RPDD cells exhibited reduced PARP1 and ARH3 expression and elevated PAR levels. Interestingly, HCT116RPDD cells exhibited slightly elevated intracellular NAD+/NADH and ATP levels. Our findings suggest a
Kaede Tsuda, Yoko Ogino, Akira Sato
wiley   +1 more source

Psychometrics of the scale of attitudes toward physician-pharmacist collaboration: a study with medical students. [PDF]

, 2012
BACKGROUND: Despite the emphasis placed on interdisciplinary education and interprofessional collaboration between physicians and pharmacologists, no psychometrically sound instrument is available to measure attitudes toward collaborative relationships ...
Fassihi, Reza, Gonnella, Joseph S., Hojat, Mohammadreza, Isenberg, Gerald A., Spandorfer, John, Vergare, Michael J.   +5 more
core   +1 more source

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Linking a Pharmaceutical Chemistry Workshop to Pharmacy Practice [PDF]

, 2014
This paper describes the design and implementation of a workshop to enhance pharmacy students’ appreciation of the importance of chemistry for pharmacy practice.
Adams, Andrew, Adams, Sylvia, Conway, Barbara, Culshaw, Margaret, Morral, Jordi, Morral, Kim   +5 more
core   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Course experiences, satisfaction and career intent of final year pre-registration Australian pharmacy students

Pharmacy Practice, 2014
Background: In Australia, the profession of pharmacy has undergone many changes to adapt to the needs of the community. In recent years, concerns have been raised with evidence emerging of workforce saturation in traditional pharmacy practice sectors. It
Shen G, Fois R, Nissen L, Saini B
doaj  

How Pharmacy Students Feel about an HIV Pre-Exposure Prophylaxis Advertising Campaign

INNOVATIONS in Pharmacy
Description: This activity prompted pharmacy students to analyze a Los Angeles Lesbian, Gay, Bisexual, and Transgender (LA LGBT) Center-generated “F**k w/out fear” HIV pre-exposure prophylaxis (PrEP) billboard campaign. Students shared their thoughts
Kenric Ware
doaj   +1 more source

In vitro anthelmintic activity and phytochemical characterization of Colchicum autumnale L. corm extract [PDF]

Trends in Pharmaceutical Sciences
Helminth infections are prevalent in poverty-stricken areas and developing countries with warm, humid climates and poor sanitary conditions. The limited availability of anthelmintic drugs and the emergence of drug resistance have prompted the search for ...
Zeenath Banu, Shara sherlin Jagannadham, Jangala Akanksha Akanksha, Aakula Nikshitha Aakula Nikshitha   +3 more
doaj   +1 more source

Nurses\u27 Alumnae Association Bulletin - Volume 17 Number 1 [PDF]

, 1952
Alumnae Notes Committee Reports Digest of Alumnae Association Meetings Greetings from Miss Childs Greetings from the Educational Director Greetings from the President Graduation Awards - 1951 Jefferson\u27s New Hospital Addition Marriages Necrology ...
Alpers, Bernard J, Boerlin, Paully Jane, Childs, Katherine, Cozza, Angela R, Flack, Herbert L, Flanagan, Jeanne, Hamrick, Hayward R, Kevel, Isabelle, Kuba, Anna, Miller, Franklin R, Nentwig, Dorothy, Piersol, Betty, Plaisted, Marilyn, Skvir, Elsie, Spruance, Henrietta Fitzgerald, Whitney, Helen M, Yaeger, Rudolph, Zeldis, William   +17 more
core   +1 more source