Results 81 to 90 of about 61,864 (315)

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Training the Next Generation of Pharmacist Educators (NextGenRxEd): Outcomes from a Longitudinal 4-Year Teaching and Research Program

Pharmacy
To combine didactic education with clinical and research experiences that would empower student pharmacists to consider postgraduate training and a career in pharmacy education or academics, in 2009, the Next Generation of Pharmacist Educators ...
Candis M. Morello, Mark Bounthavong, Jan D. Hirsch   +2 more
doaj   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

The role of nutrition education in the pharmacy curriculum using the example of knowledge about the health benefits of nuts

Frontiers in Public Health
In recent years, nuts have gained importance because of their nutritional benefits in promoting health and preventing chronic diseases. Despite their recognized role as part of healthy dietary patterns, global consumption is below recommended levels ...
Ivana Stević, Danijela Milenković, Ana Petrović, Ana Pejčić, Margarita Dodevska, Marija Prvulović Ilić, Nevena Ivanović   +6 more
doaj   +1 more source

First-Year Pharmacy Students Knowledge and Opinions of Residency or Fellowship Training After a Pharm.D. [PDF]

, 2021
Bisrat Hailemeskel
openalex   +1 more source

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

FEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde, Unai Alduntzin, Gorka Prieto, Ugo Mayor   +3 more
wiley   +1 more source

Knowledge, Attitude, and Practice Towards Responsible Self-Medication Among Pharmacy Students: A Web-Based Cross-Sectional Survey in Uganda

Drug, Healthcare and Patient Safety
Bukoli Brian,1 Narayana Goruntla,1 Bhavana Reddy Bommireddy,2 Bhavani M Mopuri,2 Vigneshwaran Easwaran,3 Mohammad Jaffar Sadiq Mantargi,4 Durga Prasad Thammisetty,5 Sarad Pawar Naik Bukke,6 Tadele Mekuriya Yadesa,1 Ebere Emilia Ayogu7 1Department of ...
Brian B, Goruntla N, Bommireddy BR, Mopuri BM, Easwaran V, Mantargi MJS, Thammisetty DP, Bukke SPN, Yadesa TM, Ayogu EE   +9 more
doaj  

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Barriers to medication counselling for people with mental health disorders: a six country study

Pharmacy Practice, 2010
Provision of medication information may improve adherence and prevent medication related problems. People with mental health disorders commonly receive less medication counselling from pharmacists than people with other common long term and persistent ...
Aaltonen SE, Laine NP, Volmer D, Gharat MS, Ruta Muceniece R, Vitola A, Foulon V, Desplenter FA, Airaksinen MS, Chen TF, Bell JS   +10 more
doaj