Results 51 to 60 of about 1,373,943 (268)
FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
EnergiesReliable performance of TRISO (tristructural isotropic) nuclear fuel depends on the interplay between its multilayer architecture and the buffer-layer microstructure, which are difficult to isolate experimentally.
Merve Gencturk, Karim Ahmed
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
, 2023 AbstractIn this chapter a new paradigm for the understanding of the physical world is developed based on phase-field type non-linear wave solutions. Two 1-dimensional wave fronts, right- and left-moving are combined to define the doubloon, the basic element of mass and space. The interface energy of a standard phase field defines the mass of elementary
Ingo Steinbach, Hesham Salama
openaire +1 more source
Phase Field Analysis of Eutectic Breakdown [PDF]
Metallurgical and Materials Transactions A, 2007 In this article, an isotropic multi-phase-field model is extended to include the effects of anisotropy and the spontaneous nucleation of an absent phase. This model is derived and compared against a published single-phase model. Results from this model are compared against results from other multiphase models; additionally, this model is used to ...
Green, J.R., Jimack, P.K., Mullis, A.M.
openaire +2 more sources
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
MathematicsThe main objective of this work was to model the failure mechanisms of brittle materials subjected to thermal and mechanical loads. A diffusive representation of the crack topology provides the basis for the regularized kinematic framework used.
Lotfi Ben Said +5 more
doaj +1 more source