Results 71 to 80 of about 12,160,809 (325)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Modeling ice cliff stability using a new Mohr–Coulomb-based phase field fracture model

Journal of Glaciology
Iceberg calving at glacier termini results in mass loss from ice sheets, but the associated fracture mechanics is often poorly represented using simplistic (empirical or elementary mechanics-based) failure criteria.
Theo Clayton, Ravindra Duddu, Tim Hageman, Emilio Martínez-Pañeda   +3 more
doaj   +1 more source

Rothe’s Method for Phase Field Problem

Trends in Computational and Applied Mathematics, 2007
In this paper, a phase-field model is considered. Analysis of a time discretization for an initial-boundary value problem for this phase-field model is presented. Convergence is proved and existence, uniqueness and regularity results are derived.
C. Vaz
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Fresnel Field Phase Retrieval via High-speed Phase Modulation

工程科学与技术, 2022
The multi-intensity phase retrieval methods obtain different coded diffraction patterns by changing the physical parameters in the optical imaging system, which can achieve the best convergence of phase and high-precision reconstruction without ...
Cheng ZHANG, Liru ZHANG, Jinbing ZHU, Jinbo JIANG, Sui WEI   +4 more
doaj  

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

The Determination of the Elastoplastic and Phase-Field Parameters for Monotonic and Fatigue Fracture of Sintered Steel Astaloy™ Mo+0.2C

Metals
This paper presents a procedure for determining the elastoplastic parameters of phase-field fracture of sintered material. The material considered was sintered steel Astaloy™ Mo+0.2C of three densities: 6.5, 6.8 and 7.1 g/cm3. The stress–strain curve and
Tomislav Polančec, Tomislav Lesičar, Zdenko Tonković   +2 more
doaj   +1 more source