Results 111 to 120 of about 959,575 (246)

A phase-field and Fourier neural operator-based method for predicting crack evolution in column-shell structures

open access: yesBaozha yu Chongji
With the increasing application of engineering structures under extreme conditions, accurately predicting their fracture behavior has become a critical challenge in materials science and fracture mechanics.
Yadong QIE   +3 more
doaj   +1 more source

Spatial biology in cancer epigenetics

open access: yesMolecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Synchronous Measurement Method of Two-phase Flow Phase Field and Concentration Field Based on Wire-mesh Sensor

open access: yesYuanzineng kexue jishu
It is crucial to understand the internal mixing behavior accurately of the fuel assemblies in the nuclear reactor which could optimize design and safety analysis.
XIA Xinyu1, 2, YAN Xu2, 3, FU Junsen2, 3, XIAO Yao1, 2, 3, , GU Hanyang2, 3
doaj   +1 more source

Topology Optimization for Microfluidic Mixers by a Phase Field Method

open access: yesInternational Journal for Numerical Methods in Fluids
ABSTRACT We investigate multi‐physical topology optimization for microfluidic mixers. Starting from the Ising model, we derive a thermodynamically consistent Ginzburg–Landau free energy functional that incorporates the objective functional as an effective external field, providing a physically interpretable framework for phase‐field ...
Liu, Zongyuan   +2 more
openaire   +2 more sources

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

open access: yesFEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj   +3 more
wiley   +1 more source

Study on the two-phase flow behavior in batch transportation of liquid ammonia and product oil

open access: yesYou-qi chuyun
Objective Batch transportation of liquid ammonia via product oil pipelines can expand transportation routes, reduce costs, and enhance pipeline efficiency to address the low throughput of existing product oil pipelines.
Xin HUANG   +7 more
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

open access: yesFEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli   +8 more
wiley   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

open access: yesFEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer   +7 more
wiley   +1 more source

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