Results 101 to 110 of about 967,094 (265)

Phase field modelling of elastic-plastic fatigue fracture of oil and gas pipeline

Materials Research Express
This paper established a fatigue fracture phase-field model (PFM) to evaluate fatigue damage evolution and crack propagation in oil and gas pipeline.
Zhen Wang, Wei He, Xin Li, Tao Lu, Shengguo Chen, Dingyu Li, Hengwei Zheng   +6 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Simple implementation examples of agent AI on free energy calculation and phase-field simulation

Science and Technology of Advanced Materials: Methods
With the development of an environment that equips large language models with tools, chat-type artificial intelligence (AI) is currently shifting to agent-type AI.
Toshiyuki Koyama, Yusuke Matsuoka, Akimitsu Ishii   +2 more
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

An Electrohydrodynamic Phase-Field Model for Contact Angle Hysteresis in Electrowetting Pixels: Decoupling Physical Pinning and Charge Trapping

Micromachines
Precise manipulation of two-phase flow in micro-confined electrowetting pixels is limited by contact angle hysteresis (CAH). To elucidate this non-equilibrium process, we establish a high-fidelity electrohydrodynamic (EHD) phase-field simulation ...
Qingsong Lu, Li Wang, Feng Li, Yanjun Yang, Qifu Liu, Xinying Wang, Feng Chi, Liming Liu, Zichuan Yi   +8 more
doaj   +1 more source

Constitutive Modelling of Sintered Steel by Phase-field Method

Procedia Structural Integrity
The phase-field method is lately one of the most popular approaches for modelling of complex fracture phenomena. As known, the displacement field and phase-field variable cannot be determined simultaneously, except for easy problems, due to non-convexity of the energy functional.
Tomislav Polančec, Tomislav Lesičar, Jakov Rako   +2 more
openaire   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

A phase-field and Fourier neural operator-based method for predicting crack evolution in column-shell structures

Baozha yu Chongji
With the increasing application of engineering structures under extreme conditions, accurately predicting their fracture behavior has become a critical challenge in materials science and fracture mechanics.
Yadong QIE, Xiang LI, Songlin YAO, Hao ZHANG   +3 more
doaj   +1 more source