Results 61 to 70 of about 222,870 (258)

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Applications of Phase Field Methods in Modeling Fatigue Fracture and Performance Improvement Strategies: A Review

Metals, 2023
Fatigue fracture simulation based on phase field methods is a promising numerical approach. As a typical continuum approach, phase field methods can naturally simulate complex fatigue fracture behavior.
Haitao Cui, Chenyu Du, Hongjian Zhang
doaj   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Investigating the Switching Dynamics of Antiferroelectric Capacitor Using Multidomain Phase-Field Approach

IEEE Journal of the Electron Devices Society
Here, we present a compact model based on multidomain phase-field approach that can capture the hysteresis loop and the transient negative capacitance (NC) regions in Metal-Antiferroelectric-Metal structures.
Muhammad Mainul Islam, Mohammad Adnaan, Sou-Chi Chang, Hai Li, Ian A. Young, Azad Naeemi   +5 more
doaj   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source

Scalable autoregressive deep surrogates for complex microstructure dynamics

Machine Learning: Science and Technology
Complex microstructural pattern formation, such as dendrite growth, occurs across a wide range of materials and plays a crucial role in determining their properties and functional performance.
Kaihua Ji, Luning Sun, Shusen Liu, Fei Zhou, Tae Wook Heo   +4 more
doaj   +1 more source

Synergistic effects of Al and Mo on coarsening kinetics of Ni-based superalloys at 1200°C

Materials Research Letters
The interaction effects of γ-strengthening and γ'-former elements have long troubled the alloying design of superalloys, especially improving γ'-thermostability by Al addition against higher temperatures.
Mingzhe Li, Wenyue Zhao, Yi Ru, Yanling Pei, Shusuo Li, Shengkai Gong   +5 more
doaj   +1 more source

A multigrid solver for phase field simulation of microstructure evolution [PDF]

Mathematics and Computers in Simulation, 2010
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Liesbeth Vanherpe, Frank Wendler, Britta Nestler, Stefan Vandewalle   +3 more
openaire   +3 more sources

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

A parallelized model for coupled phase field and crystal plasticity simulation [PDF]

Computer Methods in Materials Science, 2016
The predictive simulation of materials with strong interaction between microstructural evolution and mechanical deformation requires the coupling of two or more multi-physics models.
Mingxuan Lin, Ulrich Prahl
doaj   +1 more source