Results 51 to 60 of about 163,290 (264)
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
IEEE Open Journal of Power ElectronicsThis work presents an efficiency-oriented modulation and morphing strategy for a three-phase three-level dual active bridge converter operating across both 800 V and 400 V electric vehicle battery systems.
Lohith Kumar Pittala +6 more
doaj +1 more source
Electrically tunable harmonics in time-modulated metasurfaces for wavefront engineering
New Journal of Physics, 2018 Modulation of metasurfaces in time gives rise to several exotic space–time scattering phenomena by breaking the reciprocity constraint and generation of higher-order frequency harmonics. We introduce a new design paradigm for time-modulated metasurfaces,
Mohammad Mahdi Salary +2 more
doaj +1 more source
A Novel Switched-Capacitor Converter With High Voltage Gain
IEEE Access, 2019 In this paper, a novel topology of switched-capacitor converter is proposed. Compared with the existing switched-capacitor topologies, such as the Dickson-based switched-capacitor converter or the ladder switched-capacitor converter, it limits both ...
Hongyang Xie, Rui Li
doaj +1 more source
FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Full Bridge LLC Hybrid Control Strategy with Wide Input and Output Voltage Range
EnergiesThe LLC resonant converter has gained extensive adoption in recent years, primarily owing to its benefits including high efficiency and high power density.
Jianhua Wu +5 more
doaj +1 more source
Differential Full Diversity Spatial Modulation using Amplitude Phase Shift Keying [PDF]
Radioengineering, 2018 Diversity is a fundamental concept used to reduce the adverse effects of fading in wireless communications. Differential full diversity spatial modulation (DFD-SM) is a differential spatial modulation (DSM) scheme that makes use of a cyclic signaling ...
K. Dwarika, H. Xu.
doaj
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source