Results 51 to 60 of about 162,262 (264)
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
IEEE Open Journal of Power ElectronicsThis work presents an efficiency-oriented modulation and morphing strategy for a three-phase three-level dual active bridge converter operating across both 800 V and 400 V electric vehicle battery systems.
Lohith Kumar Pittala +6 more
doaj +1 more source
Differential Full Diversity Spatial Modulation using Amplitude Phase Shift Keying [PDF]
Radioengineering, 2018 Diversity is a fundamental concept used to reduce the adverse effects of fading in wireless communications. Differential full diversity spatial modulation (DFD-SM) is a differential spatial modulation (DSM) scheme that makes use of a cyclic signaling ...
K. Dwarika, H. Xu.
doaj
Electrically tunable harmonics in time-modulated metasurfaces for wavefront engineering
New Journal of Physics, 2018 Modulation of metasurfaces in time gives rise to several exotic space–time scattering phenomena by breaking the reciprocity constraint and generation of higher-order frequency harmonics. We introduce a new design paradigm for time-modulated metasurfaces,
Mohammad Mahdi Salary +2 more
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
A Novel Switched-Capacitor Converter With High Voltage Gain
IEEE Access, 2019 In this paper, a novel topology of switched-capacitor converter is proposed. Compared with the existing switched-capacitor topologies, such as the Dickson-based switched-capacitor converter or the ladder switched-capacitor converter, it limits both ...
Hongyang Xie, Rui Li
doaj +1 more source
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source