Results 1 to 10 of about 1,093,896 (269)

Targeting neuroinflammation as a preventive and therapeutic approach for perioperative neurocognitive disorders

Journal of Neuroinflammation, 2022
Perioperative neurocognitive disorders (PND) is a common postoperative complication associated with regional or general anesthesia and surgery. Growing evidence in both patient and animal models of PND suggested that neuroinflammation plays a critical ...
Chun Cheng, Hanxi Wan, Peilin Cong, Xinwei Huang, Tingmei Wu, Mengfan He, Qian Zhang, Lize Xiong, Li Tian   +8 more
doaj   +1 more source

Aversive stimulus-tuned responses in the CA1 of the dorsal hippocampus

Nature Communications, 2023
Throughout life animals inevitably encounter unforeseen threatening events. Activity of principal cells in the hippocampus is tuned for locations and for salient stimuli in the animals’ environment thus forming a map known to be pivotal for guiding ...
Albert M. Barth, Marta Jelitai, Maria Flora Vasarhelyi-Nagy, Viktor Varga   +3 more
doaj   +1 more source

Activity and Coupling to Hippocampal Oscillations of Median Raphe GABAergic Cells in Awake Mice

Frontiers in Neural Circuits, 2021
Ascending serotonergic/glutamatergic projection from the median raphe region (MRR) to the hippocampal formation regulates both encoding and consolidation of memory and the oscillations associated with them.
Marta Jelitai, Albert M. Barth, Ferenc Komlósi, Tamás F. Freund, Viktor Varga   +4 more
doaj   +1 more source

Activation of the Innate Immune Checkpoint CLEC5A on Myeloid Cells in the Absence of Danger Signals Modulates Macrophages’ Function but Does Not Trigger the Adaptive T Cell Immune Response

Journal of Immunology Research, 2022
C-Type lectin receptor 5A (CLEC5A) is a spleen tyrosine kinase- (Syk-) coupled pattern recognition receptor expressed on myeloid cells and involved in the innate immune response to viral and bacterial infections.
Milena J. Tosiek, Kerstin Groesser, Anton Pekcec, Monika Zwirek, Gavuthami Murugesan, Eric Borges   +5 more
doaj   +1 more source

CD83 expressed by macrophages is an important immune checkpoint molecule for the resolution of inflammation

Frontiers in Immunology, 2023
Excessive macrophage (Mφ) activation results in chronic inflammatory responses or autoimmune diseases. Therefore, identification of novel immune checkpoints on Mφ, which contribute to resolution of inflammation, is crucial for the development of new ...
Katrin Peckert-Maier, Pia Langguth, Astrid Strack, Lena Stich, Petra Mühl-Zürbes, Christine Kuhnt, Christina Drassner, Elisabeth Zinser, Marius Wrage, Jochen Mattner, Alexander Steinkasserer, Dmytro Royzman, Andreas B. Wild   +12 more
doaj   +1 more source

HSV-1 Modulates IL-6 Receptor Expression on Human Dendritic Cells

Frontiers in Immunology, 2020
Dendritic cells (DCs) are the guardians of the immune system since they are located in the majority of peripheral tissues. In addition, they are crucial for the induction of an effective immune response based on their unique capacity to stimulate naive T
Alexandra Birzer, Adalbert Krawczyk, Adalbert Krawczyk, Christina Draßner, Christine Kuhnt, Petra Mühl-Zürbes, Christiane Silke Heilingloh, Christiane Silke Heilingloh, Alexander Steinkasserer, Linda Popella   +9 more
doaj   +1 more source

Soluble CD83 modulates human-monocyte-derived macrophages toward alternative phenotype, function, and metabolism

Frontiers in Immunology, 2023
Alterations in macrophage (Mφ) polarization, function, and metabolic signature can foster development of chronic diseases, such as autoimmunity or fibrotic tissue remodeling. Thus, identification of novel therapeutic agents that modulate human Mφ biology
Katrin Peckert-Maier, Andreas B. Wild, Laura Sprißler, Maximilian Fuchs, Philipp Beck, Jean-Philippe Auger, Pia Sinner, Astrid Strack, Petra Mühl-Zürbes, Ntilek Ramadan, Meik Kunz, Meik Kunz, Gerhard Krönke, Lena Stich, Alexander Steinkasserer, Dmytro Royzman   +15 more
doaj   +1 more source

Towards optimising experimental quantification of persistent pain in Parkinson’s disease using psychophysical testing

npj Parkinson's Disease, 2021
People with Parkinson’s disease (PD) may live for multiple decades after diagnosis. Ensuring that effective healthcare provision is received across the range of symptoms experienced is vital to the individual’s wellbeing and quality of life.
Kirsty Bannister, Rory V. Smith, Patrick Wilkins, Tatum M. Cummins   +3 more
doaj   +1 more source

Quotient Module of Z-module [PDF]

Formalized Mathematics, 2012
Summary In this article we formalize a quotient module of Z-module and a vector space constructed by the quotient module. We formally prove that for a Z-module V and a prime number p, a quotient module V/pV has the structure of a vector space over Fp.
Yuichi Futa, Hiroyuki Okazaki, Yasunari Shidama   +2 more
openaire   +2 more sources

The CD83 Molecule – An Important Immune Checkpoint

Frontiers in Immunology, 2020
The CD83 molecule has been identified to be expressed on numerous activated immune cells, including B and T lymphocytes, monocytes, dendritic cells, microglia, and neutrophils.
Linda Grosche, Ilka Knippertz, Christina König, Dmytro Royzman, Andreas B. Wild, Elisabeth Zinser, Heinrich Sticht, Yves A. Muller, Alexander Steinkasserer, Matthias Lechmann   +9 more
doaj   +1 more source