Results 31 to 40 of about 58,862 (263)
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Multidimensional Polynomial Phase Estimation
IEEE Open Journal of Signal ProcessingAn estimation method is presented for polynomial phase signals, i.e., those adopting the form of a complex exponential whose phase is polynomial in its indices. Transcending the scope of existing techniques, the proposed estimator can handle an arbitrary
Heedong Do, Namyoon Lee, Angel Lozano
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Isoclinic Ambiguity Unwrapping of Circular Ring under Diametric Compression
EPJ Web of Conferences, 2010 Isoclinic and isochromatic parameters in photoelastic analysis are formulated by arc tangent function of several phase shifting frames but for isochromatic calculation it is, in addition, in terms of isoclinic data also.
Huang M.-J.
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Atmosphere, 2022 In this paper, a dual-polarization weather radar echo signal simulation method is proposed for the evaluation of the performance enhancement of dual-polarization weather radar systems, the optimization of signal processing algorithms and the improvement ...
Shaojun Dai +6 more
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Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Ambiguity of mapping the relative phase of blood pulsations
Biomedical Optics Express, 2014 Blood pulsation imaging (BPI) is a non-invasive optical method based on photoplethysmography (PPG). It is used for the visualization of changes in the spatial distribution of blood in the microvascular bed. BPI specifically allows measurements of the relative phase of blood pulsations and using it we detected a novel type of PPG fast waveforms, which ...
Teplov V. +4 more
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Phase-shift ambiguities for analytic amplitudes [PDF]
Il Nuovo Cimento A, 1973 We investigate ambiguities in reconstructing a unitary elastic amplitude at fixed energy given the differential cross-section when one assumes analyticity in the cos ϕ plane. Strong hints are given that not more than a twofold nontrivial ambiguity is present. This is demonstrated for genuine entire functions of finite order.
C. Itzykson, A. Martin
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FEBS Open Bio, EarlyView.This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
wiley +1 more source