Results 121 to 130 of about 5,504,773 (297)

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Promoting homogeneous tungsten doping in LiNiO2 through a grain boundary phase induced by excessive lithium

Advanced Powder Materials
LiNiO2 (LNO) is one of the most promising cathode materials for lithium-ion batteries. Tungsten element in enhancing the stability of LNO has been researched extensively.
Junjie Wang, Yucen Yan, Zilan Zhao, Jiayi Li, Gui Luo, Duo Deng, Wenjie Peng, Mingxia Dong, Zhixing Wang, Guochun Yan, Huajun Guo, Hui Duan, Lingjun Li, Shihao Feng, Xing Ou, Junchao Zheng, Jiexi Wang   +16 more
doaj   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Temperature-dependent deformation of methane hydrate within phase boundary

Journal of Materials Research and Technology
Natural gas hydrates preserve a huge amount of methane, yet are highly sensitive to temperature fluctuations, especially under conditions close to the phase equilibrium boundary.
Yuan Zhou, Yanlong Li, Zhengcai Zhang, Minhui Qi, Yunkai Ji, Qingguo Meng, Yilin Fu, Nengyou Wu   +7 more
doaj   +1 more source

Modulation of the morphotropic phase boundary for high-performance ductile thermoelectric materials. [PDF]

Nat Commun, 2023
Liang J, Liu J, Qiu P, Ming C, Zhou Z, Gao Z, Zhao K, Chen L, Shi X.   +8 more
europepmc   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Insight into Interface Behaviors to Build Phase-Boundary-Matched Na-Ion Direct Liquid Fuel Cells

, 2018
One of the targets associated with developing high-performance alkaline direct liquid fuel cells is to maximize the utilization of catalysts and minimize the limitation of anion materials that suffer from low ion conductivity and thermal and chemical ...
Ying Feng, Yinshi Li (5743649), Xianda Sun, Yinshi Li, Xianda Sun (5743652), Ying Feng (151159)   +5 more
core   +1 more source

Hydrodynamics in Two-Phase Turbulent Boundary Layers

Journal of Applied Fluid Mechanics, 2018
The corrections for log law must be taken into account the presence of bubbles in the two phase turbulent boundary layer. In the present study, a logarithmic law for the wall based on the supposition of additional turbulent viscosity associated with ...
M. Dhahri, H. Aouinet
doaj  

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source