Results 21 to 30 of about 23,378 (222)
An integrated simulation model towards laser powder bed fusion in-situ alloying technology
Materials & Design, 2023 The Laser Powder Bed Fusion (LPBF) in-situ alloying is a novel technology for preparing novel alloys efficiently. However, the narrow process window limit its application. A micro-scale integrated simulation model is designed and constructed based on the
Yaqing Hou +6 more
doaj +1 more source
Molecular Oncology, EarlyView.A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath +13 more
wiley +1 more source
Journal of Advanced CeramicsHigh-entropy structures in layered compounds, especially transitional metal dichalcogenides (TMDCs), have powered the field with disordered and versatile chemical compositions, showing great potential in various functional applications, including energy ...
Hongxiang Chen +8 more
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Screening for lung cancer: A systematic review of overdiagnosis and its implications
Molecular Oncology, EarlyView.Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz +12 more
wiley +1 more source
Materials & DesignThis study investigates a CrFeCoNiCu high-entropy alloy (HEA) exhibiting hierarchical phase separation into Cu-rich low-entropy (LE) and CrFeCoNi-rich high-entropy (HE) regions, driven by a miscibility gap and monotectic reaction.
Jinyeon Kim +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece +18 more
wiley +1 more source
npj Computational MaterialsHigh-entropy alloys (HEAs) have attracted increasing attention due to their unique structural and functional properties. In the study of HEAs, thermodynamic properties and phase stability play a crucial role, making phase diagram calculations ...
Siya Zhu +2 more
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Floquet conformal field theories with generally deformed Hamiltonians
SciPost Physics, 2021 In this work, we study non-equilibrium dynamics in Floquet conformal field theories (CFTs) in 1+1D, in which the driving Hamiltonian involves the energy-momentum density spatially modulated by an arbitrary smooth function.
Ruihua Fan, Yingfei Gu, Ashvin Vishwanath, Xueda Wen
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Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source