Results 101 to 110 of about 4,298,588 (299)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Computing phase diagrams using a convex hull algorithm

Astronomy & Astrophysics
We present a simple universal computational algorithm for computing compositional phase diagrams of rocks and their melts at a given temperature and pressure.
Dullemond C. P., Young E. D.
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

On the Completeness of Spider Diagrams Augmented with Constants [PDF]

, 2013
Diagrammatic reasoning can be described formally by a number of diagrammatic logics; spider diagrams are one of these, and are used for expressing logical statements about set membership and containment. Here, existing work on spider diagrams is extended
Howse, John, Peter Chapman, Simon Thompson, John Taylor, Taylor, John, Gem Stapleton, John Howse, Thompson, Simon, Stapleton, Gem, Chapman, Peter   +9 more
core   +1 more source

Enhanced microemulsion formation in lipid-based drug delivery systems by combining mono-esters of mediumchain fatty acids with di- or tri-esters

Journal of Excipients and Food Chemicals, 2016
To develop strategies for selecting appropriate lipids from mono-, di- and tri-esters of medium-chain fatty acids for the development of lipid-based drug delivery systems, ternary phase diagrams of propylene glycol (PG) monocaprylate (Capryol® 90; HLB~7),
Darshil P. Patel, Ping Li, Abu T. M. Serajuddin   +2 more
doaj  

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Drawing Area-Proportional Euler Diagrams Representing Up To Three Sets [PDF]

, 2013
Area-proportional Euler diagrams representing three sets are commonly used to visualize the results of medical experiments, business data, and information from other applications where statistical results are best shown using interlinking curves ...
Howse, John, Rodgers, Peter, Flower, Jean, Stapleton, Gem   +3 more
core   +1 more source

New Ferritic Stainless Steel for Service Temperatures up to 1050 °C Utilizing Intermetallic Phase Transformation

Metals, 2019
A large number of thermodynamic simulations has been used to design a new Nb-Ti dual stabilized ferritic stainless steel with excellent creep resistance at 1050 °C through an optimal volume fraction of Laves (η) phase stabilized by the alloying
Timo Juuti, Timo Manninen, Sampo Uusikallio, Jukka Kömi, David Porter   +4 more
doaj   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

SketchSet: Creating Euler diagrams using Pen or Mouse [PDF]

, 2011
Euler diagrams form the basis of various visual languages but tool support for creating them is generally limited to generic diagram editing software using mouse and keyboard interaction.
A. Delaney, Schmeider, Paul, Plimmer, Beryl, Delaney, Aidan, Wang, Mengdi, G. Stapleton, Rodgers, Peter, P. Schmieder, null Mengdi Wang, P. Rodgers, Stapleton, Gem, Schmieder, Paul, B. Plimmer   +12 more
core   +1 more source