Results 121 to 130 of about 251,123 (306)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Dissolution behaviour of a binary mixture in a capillary tube

We develop a pore-level physical model for the process of miscible displacement through porous media. Using the network model, the current task is reduced to the study of the dissolution dynamics of a binary mixture within a single capillary tube.
Vorobev, Anatoliy, Stevar, M.S.P.
core  

Correction for displacement artifacts in phase contrast magnetic resonance imaging

, 2001
Magnetic resonance imaging (MRI) is an imaging modality which provides good conditions for studies of flow and motion in the cardiovascular system. A variety of different imaging pulse sequences enables both anatomical and functional studies.
Thunberg, Per,
core  

Study on gas-water two-phase seepage law and flow characteristics of the matrix-fracture system in shale gas reservoirs.

PLoS ONE
As a clean energy source, shale gas plays a vital role in supporting China's strategic objectives of carbon peaking and carbon neutrality through its efficient development.
Sijie He, Feifei Fang, Jin Chang, Xizhe Li, Ruilan Luo, Jie Zhang   +5 more
doaj   +1 more source

Research on electrostatically driven MEMS optical phase shifter with integrated comb capacitive displacement sensor

Gongneng cailiao yu qijian xuebao
We designed and fabricated an electrostatically actuated micro-electro-mechanical system (MEMS) optical phase shifter incorporating a comb capacitive displacement sensor. To overcome the technical challenges of high driving voltage and inadequate control
Yuwei HAN, Yuhu XIA, Biqing ZHOU, Minli CAI, Xiaoyue WANG, Yaming WU   +5 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Programming colloidal phase transitions with DNA strand displacement

, 2016
DNA-grafted nanoparticles have been called “programmable atom-equivalents”: Like atoms, they form three-dimensional crystals, but unlike atoms, the particles themselves carry information (the sequences of the grafted strands) that can be used to “program”
Rogers, William, Manoharan, Vinothan
core   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Study on the Characteristics of CO₂ Displacing Non-Newtonian Fluids

Lubricants
CO2 displacement is a key technique that was examined through numerical methods in a 3D Hele–Shaw cell, with CO2 as the displacing phase and shear-thinning fluids as the displaced phase.
Yu-Ting Wu, Sung-Ki Lyu, Zhen Qin, Yanjun Qin, Hua Qiao, Bing Li   +5 more
doaj   +1 more source