Results 101 to 110 of about 251,123 (306)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Phase shift of the current under a single-phase short-circuit in the stator winding of a turbogenerator with double winding per phase [PDF]
, 2015 © 2015, Springer-Verlag Berlin Heidelberg. An equivalent model of a faulty turbogenerator under a single-phase short-circuit in the stator winding is presented.
Fja?kowski, Zbigniew, Nouri, Hassan
core +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Improving infrastructure responses in the phases of displacement
, 2021 Climate change has increased the global number of natural disasters and resulted in historic numbers of human displacement. Despite this surge in global displacement, multilateral policies have been slow to adapt. Because policy has been slow to change, infrastructure managers often have to rely on outdated or inadequate methods to respond during the ...
openaire +4 more sources
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
, 2012 The present paper deals with the use of simulated experiments to improve the design of an actual mechanical test. The analysis focused on the identification of the orthotropic properties of composites using the unnotched Iosipescu test and a full-field ...
Fabrice Pierron +4 more
core +1 more source
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
Pressure Behavior in a Linear Porous Media for Partially Miscible Displacement of Oil by Gas
Miscible gas flooding improves oil displacement through mass exchange between oil and gas phases. It is one of the most efficient enhanced oil recovery methods for intermediate density oil reservoirs.
Adolfo P. Pires +3 more
core +1 more source
, 2021 ในงานวิจัยฉบับนี้เป็นการสร้างเครื่องมือวัดอัตราส่วนแรงดันไฟฟ้าและตรวจสอบการกระจัดเฟสของหม้อแปลงไฟฟ้าจำหน่ายแบบ 1 เฟส และ 3 เฟส การตรวจสอบมี 2 แบบ คือ การตรวจสอบอัตราส่วนของแรงดันไฟฟ้าระหว่างขดลวดปฐมภูมิกับขดลวดทุติยภูมิและการตรวจสอบเวคเตอร์กรุ๊ปของหม ...
สื่อเฉย, บุญเลิศ +2 more
core
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source