Results 51 to 60 of about 1,443,184 (294)

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Phase Equilibrium Study of Rare Earth Oxide–Fluoride Salt System: A Review

Metals
The applications of rare earth metals and alloys are becoming increasingly widespread and there is a strong market demand. Currently, most of the production enterprises adopt the fluoride–oxide system for electrolytic preparation of rare earth metals and
Quan Zhou, Jinfa Liao, Chunfa Liao, Baojun Zhao   +3 more
doaj   +1 more source

Nonequilibrium quantum criticality in open electronic systems

, 2006
A theory is presented of quantum criticality in open (coupled to reservoirs) itinerant electron magnets, with nonequilibrium drive provided by current flow across the system. Both departures from equilibrium at conventional (equilibrium) quantum critical
A. J. Millis, Aditi Mitra, H. Risken, L. V. Keldysh, L. V. Keldysh, S. Sachdev, So Takei, Yong Baek Kim   +7 more
core   +1 more source

Chirality in Liquid Crystals: from Microscopic Origins to Macroscopic Structure [PDF]

, 1997
Molecular chirality leads to a wonderful variety of equilibrium structures, from the simple cholesteric phase to the twist-grain-boundary phases, and it is responsible for interesting and technologically important materials like ferroelectric liquid ...
Harris, A. B., Kamien, Randall D., Lubensky, T. C., Yan, Gu   +3 more
core   +4 more sources

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Investigation of methane/drilling mud phase behavior and its influence to hydrocarbon drilling activity

Energy Science & Engineering, 2019
Knowledge of methane dissolution behavior in drilling mud is of major importance to early kick detection and well control operation in oil and gas drilling industry.
Jian Feng, Jianhong Fu, Ping Chen, Liqun Xu   +3 more
doaj   +1 more source

Spin Glasses: Model systems for non-equilibrium dynamics

, 2003
Spin glasses are frustrated magnetic systems due to a random distribution of ferro- and antiferromagnetic interactions. An experimental three dimensional (3d) spin glass exhibits a second order phase transition to a low temperature spin glass phase ...
Bert F Dupuis V Vincent E Hammann J Bouchaud J-P, Cannella V, d?Almeida J R L, Fisher D S, Fisher D S, Gardchareon A, Hansen M F, Jönsson P, Jönsson P E Mathieu R Yoshino H Nordblad P Aruga Katori H Ito A, Lefloch L, Mathieu R, Per Nordblad   +11 more
core   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

SpiDec: Computing binodals and interfacial tension of biomolecular condensates from simulations of spinodal decomposition

Frontiers in Molecular Biosciences, 2022
Phase separation of intrinsically disordered proteins (IDPs) is a phenomenon associated with many essential cellular processes, but a robust method to compute the binodal from molecular dynamics simulations of IDPs modeled at the all-atom level in ...
Konstantinos Mazarakos, Ramesh Prasad, Huan-Xiang Zhou, Huan-Xiang Zhou   +3 more
doaj   +1 more source