Results 71 to 80 of about 398,169 (307)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Influence of Gas Composition on Gas Hydrate Stability Zones in the Northern South China Sea
Journal of Marine Science and EngineeringEvaluation of gas hydrate stability in marine sediments is commonly conducted assuming pure methane systems, although increasing drilling and logging evidence indicates that natural gas hydrates frequently contain minor amounts of heavier hydrocarbons ...
Qian Huang +3 more
doaj +1 more source
Thermodynamic re-assessment of the Al-Sn-Zn ternary system [PDF]
Journal of Mining and Metallurgy. Section B: Metallurgy, 2019 In this paper, a thermodynamic re-assessment of the Al-Sn-Zn ternary system was performed by means of the CALculation of PHAse Diagram (CALPHAD) approach.
Cheng T., Zhang L.-J.
doaj +1 more source
Phase change convective heat transfer in high porosity cellular metal foams [PDF]
, 2013 This Chapter discusses phase change convective heat transfer of high porosity cellular metal foams and their practical applications in thermal energy storage (TES).
Zhao, Changying, Tian, Yuan, Wang, Qian
core
Gibbs energy minimization with cubic equation of state and Henry's law to calculate thermodynamic equilibrium of Fischer-Tropsch synthesis [PDF]
, 2020 Fischer-Tropsch synthesis (FTS) is a catalytic process to convert synthesis gas ( and CO) into fuels, as diesel and gasoline. It is an alternative to produce renewable fuels from raw materials such as biomass.
Guirardello, Reginaldo +1 more
core +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Journal of Thermal Science and Technology, 2013 In binary systems of hydrogen and hydrocarbons, the fluid-phase thermodynamic behavior is unique in having the divergence of the critical curves to a high pressure region. The thermodynamic properties of the binary systems including hydrogen with methane,
Naoya SAKODA +2 more
doaj +1 more source
Upscaling multi-component two-phase flow in porous media with partitioning coefficient [PDF]
, 2011 This paper deals with the upscaling of multicomponents two-phase flow in porous media. In this paper, chemical potential equilibrium at the interface between both phases is assumed to be described by a linear partitioning relationship such as Raoult or ...
Quintard, Michel +5 more
core +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source