Results 91 to 100 of about 398,169 (307)

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

open access: yesFEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong   +3 more
wiley   +1 more source

Effect of particle size, water saturation, inorganic salt and methane on the phase equilibrium of CO2 hydrates in sediments [PDF]

open access: yes
Understanding the thermal stability of gas hydrate in complex marine geological environment is of importance to hydrate-based carbon sequestration. In this work, the factors affecting the equilibrium of CO2 hydrate in ocean sediments, including quartz ...
Xu, Chenlu   +5 more
core   +3 more sources

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

open access: yesFEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero   +5 more
wiley   +1 more source

Benedict–Webb–Rubin–Starling Equation of State + Hydrate Thermodynamic Theories: An Enhanced Prediction Method for CO2 Solubility and CO2 Hydrate Phase Equilibrium in Pure Water/NaCl Aqueous Solution System

open access: yesEnergies
Accurately predicting the phase behavior and physical properties of carbon dioxide (CO2) in pure water/NaCl mixtures is crucial for the design and implementation of carbon capture, utilization, and storage (CCUS) technology.
Changyu You   +5 more
doaj   +1 more source

Modeling and computation of two phase geometric biomembranes using surface finite elements [PDF]

open access: yes, 2010
Biomembranes consisting of multiple lipids may involve phase separation phenomena leading to coexisting domains of different lipid compositions.
Stinner, Björn, Elliott, Charles M.
core   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

open access: yesFEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana   +5 more
wiley   +1 more source

Functional and Structural Evidence of Neurofluid Circuit Aberrations in Huntington Disease

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Disrupted neurofluid regulation may contribute to neurodegeneration in Huntington disease (HD). Because neurofluid pathways influence waste clearance, inflammation, and the distribution of central nervous system (CNS)–delivered therapeutics, understanding their dysfunction is increasingly important as targeted treatments emerge.
Kilian Hett   +8 more
wiley   +1 more source

Equilibrium distributions of discrete phase type [PDF]

open access: yes, 2013
It is well known that the family of discrete phase-type distributions is closed under convolutions, mixtures, and the unary “geometric mixture” operation. In this article, we show that the equilibrium distributions of this family are again of phase type.
Wu, X
core   +1 more source

A Prospective Study of Individuals at Risk of Multiple Sclerosis Informs the Design of Primary Prevention Studies

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective In multiple sclerosis, the optimal time for deploying a therapeutic intervention is before the central nervous system is damaged; given the success of trials treating the earliest stage of MS, the radiologically isolated syndrome, developing primary prevention strategies is an important next challenge.
Amy W. Laitinen   +7 more
wiley   +1 more source

Phase Equilibrium and Dissociation Enthalpies for Cyclopentane plus Methane Hydrates in NaCl Aqueous Solutions [PDF]

open access: yes, 2010
The phase equilibrium data of cyclopentane (CP) + methane hydrates in brine water with NaCl mass fractions of w = 0.0.035, 0.070, and 0.100 were measured in the temperature range (284.4 in 301.3) K using a visual high-pressure phase equilibrium apparatus.
Qing-Ping Li   +11 more
core   +1 more source

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