Results 71 to 80 of about 21,073,531 (290)

Numerical Simulation of Polarization and Deformation of Droplet under Pulsed Electric Field

Shiyou jixie, 2019
To deeply explore the electric dehydration mechanism under pulsed electric field, a two-dimensional model of the polarization and deformation of water-in-oil emulsion droplet under pulsed electric field is established based on COMSOL technology and using
Sun Zhiqian, Fan Yuling, Zhang Mengqi, Li Bin, Wang Zhenbo, Huang Mei   +5 more
doaj  

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Study on Elastoplastic Damage and Crack Propagation Mechanisms in Rock Based on the Phase Field Method

Applied Sciences
To overcome the limitation of traditional elastic phase field models that neglect plastic deformation in rock compressive-shear failure, this study developed an elastoplastic phase field fracture model incorporating plastic strain energy and established ...
Jie Zhang, Guang Qin, Bin Wang
doaj   +1 more source

A modified damage and fracture phase field model considering heterogeneity for rock‐like materials

Deep Underground Science and Engineering, 2023
Damage and fracture are the most extensive failure modes of rock materials, which may easily induce disaster and instability of engineering structures.
Xuxin Chen, Zhe Qin
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Phase-field modeling of thermo-mechanical coupled brittle fracture for transversely isotropic rock

Yantu gongcheng xuebao
Thermally induced deformation and fracture of bedding rocks are critical concerns in geotechnical engineering, including geothermal mining and nuclear waste storage, as these phenomena are strongly influenced by material anisotropy.
ZHANG Chengkai 1, 2, ZHOU Shuwei 1, 2, ZHANG Yuheng 1, 2, TIAN Junyao 1, 2, ZHUANG Xiaoying 1, 2
doaj   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source