Results 91 to 100 of about 1,024,086 (309)

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Advanced operator splitting based semi-implicit spectral method to solve the binary and single component phase-field crystal model

, 2011
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.We present extensive testing in order to find the optimum balance among errors associated with time integration, spatial discretization, and splitting for a
Bansel, Gurvinder Singh
core  

Integrable multi-phase thermodynamic systems and Tsallis' composition rule

, 2014
We derive a class of equations of state for a multi-phase thermodynamic system associated with a finite set of order parameters that satisfy an integrable system of hydrodynamic type. As particular examples, we discuss one-phase systems such as the van
de Nittis, Giuseppe, Moro, Antonio, Lorenzoni, Paolo   +2 more
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

A Phase Field Model for Continuous Clustering on Vector Fields [PDF]

, 2001
A new method for the simplification of flow fields is presented. It is based on continuous clustering. A well-known physical clustering model, the Cahn Hilliard model, which describes phase separation, is modified to reflect the properties of the data to
Preusser, T, Preußer, Tobias,, Telea, Alexandru C., Garcke, H., Rumpf, M, Wijk, Jarke J. van,, Wijk, JJ Jarke = Jack van, Weikard, U., Telea, Alexandru C.,, Preusser, T., Telea, A.C., Garcke, Harald,, Rumpf, Martin,, Weikard, Ulrich,, Wijk, Jarke J. van, Garcke, Harald, Wijk, van, J.J., Rumpf, Martin, Weikard, U, Rumpf, M., Garcke, H, Preußer, Tobias, Telea, AC Alexandru, Weikard, Ulrich   +23 more
core   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Slow-light and evanescent modes at interfaces in photonic crystal waveguides: optimal extraction from experimental near-field measurements [PDF]

, 2011
We develop a systematic approach for simultaneous extraction of the dispersion relations and profiles of multiple modes in periodic waveguides though a special global optimization procedure applied to near-field electric field measurements in the ...
Ha, S., de Sterke, C. Martijn, Yuri S. Kivshar, Krauss, T.F., Sterke, C.M. de, Spasenovic, Marko, White, Tom P, Sukhorukov, Andrey A., Krauss, Thomas Fraser, Thomas F. Krauss, White, T.P., Sangwoo Ha, Kuipers, L.K. (Kobus), Sukhorukov, A.A., Kivshar, Y.S. (Yuri), Thomas P. White, Andrey A. Sukhorukov, Kuipers, L. Kobus, L. (Kobus) Kuipers, Spasenović, M., Marko Spasenović, C. Martijn de Sterke, Ha, Sangwoo, Kivshar, Yuri S.   +23 more
core   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Potential damage surfaces and their control in abandoned mine caverns for compressed hydrogen energy storage

Meitan kexue jishu
Retrofitting abandoned mine shafts and using them for compressed hydrogen energy storage is an effective way to reuse waste resources and to realize the “double carbon” strategy.
Rui LIU, Shuwei ZHOU, Shikang QIN, Xiuhan HE, Jianye FENG, Xiaodong ZHENG   +5 more
doaj   +1 more source