Results 91 to 100 of about 961,151 (262)
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Numerical investigation of electrocoalescence-induced fluid demixing between parallel plates
European Mechanical ScienceThe efficient separation of dispersed phase droplets from a continuous phase in multiphase flow systems is essential for industries such as petroleum refining, pharmaceuticals, and food production.
Aslı Tiktaş
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Molecular Oncology, EarlyView.This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant +11 more
wiley +1 more source
Numerical simulation of boundary heat flow effects on directional solidification microstructure of a binary alloy [PDF]
China Foundry, 2010 The boundary heat flow has important significance for the microstructures of directional solidified binary alloy. Interface evolution of the directional solidified microstructure with different boundary heat flow was discussed.
Xue Xiang, Tang Jinjun
doaj
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
ADP‐ribosylation: An emerging regulator of the epigenome
Molecular Oncology, EarlyView.ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho +2 more
wiley +1 more source
Simulation of CO2–water two‐phase fluid displacement characteristics based on the phase field method
Deep Underground Science and EngineeringThe two‐phase flow in porous media is affected by multiple factors. In the present study, a two‐dimensional numerical model of porous media was developed using the actual pore structure of the core sample.
Changnü Zeng +3 more
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Comprehensive Investigation of Factors Affecting Acid Fracture Propagation with Natural Fracture
EnergiesAcid fracturing is a crucial stimulation technique to enhance hydrocarbon recovery in carbonate reservoirs. However, the interaction between acid fractures and natural fractures remains complex due to the combined effects of mechanical, chemical, and ...
Qingdong Zeng +4 more
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Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae
FEBS Open Bio, EarlyView.Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj +3 more
wiley +1 more source