Results 101 to 110 of about 4,563,981 (306)

The role of cooling flows in galaxy formation

open access: yes, 1995
The present structure of galaxies is governed by the radiative dissipation of the gravitational and supernova energy injected during formation. A crucial aspect of this process is whether the gas cools as fast as it falls into the gravitational potential
Fabian, A. C., Nulsen, P. E. J.
core   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

open access: yesFEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López   +2 more
wiley   +1 more source

The Milky Way as a High Redshift Galaxy: The Importance of Thick Disk Formation in Galaxies

open access: yes, 2014
We compare the star-formation history and dynamics of the Milky Way (MW) with the properties of distant disk galaxies. During the first ~4 Gyr of its evolution, the MW formed stars with a high star-formation intensity (SFI), Sigma_SFR~0.6 Msun/yr/kpc2 ...
Di Matteo, Paola   +3 more
core   +2 more sources

Phase Pattern Formation in Grain Boundaries

open access: yesPhysical Review Letters
In this Letter we derive conditions that predict the existence of two-phase periodic-pattern grain boundary structures that are stable against coarsening. While previous research has established that elastic effects can lead to phase pattern formation on crystal surfaces, the possibility of stable grain boundary structures composed of alternating grain
I. S. Winter, T. Frolov
openaire   +3 more sources

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

Boron in Palladium: interaction, phase formation and phase transformation

open access: yes, 2001
The principles for the formation of interstitial solid solution have been described in the past by rules, taking in consideration elastic relationships between solvent and solute atoms. These rules are not applicable on the formation of the solid solution of the late transition metals (a-Co, Rh, Ir, Ni, Pd, Pt) and boron.
openaire   +3 more sources

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Quasicrystalline Phase Formation of the Al67Cu26Fe15 Alloy

open access: yesSemina: Ciências Exatas e Tecnológicas, 2019
The present work aimed to characterize the microstructure of the icosahedral phase (quasicrystalline phase-f)of the system with stoichiometric composition of the quasicrystal Al67Cu26Fe15.
Luciano Nascimento, Anastasiia Melnyk
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

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