Results 111 to 120 of about 5,552,824 (295)

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Communication: Analytic gradients in the random-phase approximation

The Journal of Chemical Physics, 2013
The relationship between the random-phase-approximation (RPA) correlation energy and the continuous algebraic Riccati equation is examined and the importance of a stabilizing solution is emphasized. The criterion to distinguish this from non-stabilizing solutions can be used to ensure that physical, smooth potential energy surfaces are obtained.
Rekkedal, J, CORIANI, Sonia, Iozzi, M. F., Teale, A. M., Helgaker, T., Pedersen, T. B.   +5 more
openaire   +4 more sources

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Phase-Contrast-Cine pulse sequence.

, 2017
Phase-Contrast-Cine pulse sequence to measure global and local pulse wave velocities (PWV). The sequence was repeated five times (segment loop) starting with a variable delay Δt = (0ms, 1ms, 2ms, 3ms, 4ms) thus yielding to an effective temporal ...
Peter Nordbeck (448724), Volker Herold (3753226), Peter M. Jakob (337273), Eberhard Rommel (3753232), Patrick Winter (3753235), Alexander Gotschy (3753229), Wolfgang R. Bauer (235378)   +6 more
core   +1 more source

A compressible mixture model with phase transition [PDF]

, 2013
We introduce a new thermodynamically consistent diffuse interface model of Allen--Cahn/Navier--Stokes type for multi-component flows with phase transitions and chemical reactions.
Giesselmann, Jan, Kraus, Christiane, Dreyer, Wolfgang   +2 more
core   +1 more source

Gradient-based delay optimisation framework for acoustic metasurfaces coupled with real loudspeakers

This study presents a method for tailoring the acoustic emission of a commercial loudspeaker using a passive metasurface placed in front of it. The metasurface is optimised using a gradient-descent algorithm, made computationally feasible by modelling it
Letizia Chisari (12532264), Andy Philippides (14138817), Gianluca Memoli (1875418)   +2 more
core   +2 more sources

A role for eIF5A in translational control of stress‐inducible proteins in multiple myeloma cell lines

Molecular Oncology, EarlyView.
Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both, Ingrid A. M. Derks, Raphaël Vanleyssem, Marine Leclercq, Najla El Hachem, Pierre Close, Eric Eldering, Marco Vincent Haselager   +7 more
wiley   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Enhanced control of transmission/reflection amplitudes using a closed-form slowly varying phase-gradient metasurface GSTC framework

Scientific Reports
Although the generalized Snell’s law qualitatively predicts the effect of the phase gradient on wave impedance and parasitic diffractions, a closed-form quantitative relationship among transmission/reflection coefficients, phase gradient, incidence angle,
Mehri Hosseini, Mohammad Mahdi Taskhiri
doaj   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source