Results 91 to 100 of about 5,552,824 (295)

Comparing the paths of Hedgehog release in artificial and natural settings

FEBS Letters, EarlyView.
Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Mobile phase transition program by gradient method.

Mobile phase transition program by gradient method.
Sogand Solouki (18389219), Hanieh Jafary (18389225), Sattar Gorgani-Firuzjaee (18389222), Maryam Delfan (18389228)   +3 more
core   +1 more source

The composition of the mobile phase and the gradient program.

, 2013
The composition of the mobile phase and the gradient program.
Fang Zhou (43765), Fang Niu (316587), Guangji Wang (141875), Jingwei Zhang (288128), Meng Lu (271376), Jianguo Sun (140433), Xiaolan Wu (148266)   +6 more
core   +1 more source

Investigating Pressure Gradient Dynamics in Two-phase Fluid Flow through Porous Media: An Experimental and Numerical Analysis [PDF]

Journal of Applied Fluid Mechanics
This study investigates pressure gradient dynamics within a porous medium in the context of two-phase fluid flow, specifically water and sand particle interactions.
H. Ashouri, H. Mohammadiun, M. Mohammadiun, G. Shafiee Sabet, M. H. Dibaee Bonab, F. Sabbaghzadeh   +5 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Scintillation modeling with random phase gradient screens

Journal of Space Weather and Space Climate
Multiple studies of scintillation phenomena have shown that, in certain situations, the intense phase fluctuations of trans-ionospheric radio signals are associated with the scattering on strong electron density gradients.
Vasylyev Dmytro, Cahuasquí Juan Andrés, Hoque Mainul, Jakowski Norbert, Kriegel Martin, David Paul, Tagargouste Youssef, Buchert Stephan, Berdermann Jens   +8 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Phase Extraction Algorithm Based on the Spatial Carrier-Frequency Phase-Shifting Gradient

IEEE Photonics Journal, 2019
For improving the accuracy and processing speed of phase extraction, a new phase extraction algorithm based on the spatial carrier-frequency phase-shifting gradient (SCFPS-G) is proposed.
Haoren Zou, Liyun Zhong, Jiaosheng Li, Zhenda Sun, Yicheng Liu, Qinwen Ning, Xiaoxu Lu   +6 more
doaj   +1 more source