Results 61 to 70 of about 560,798 (337)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

open access: yesMolecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir   +12 more
wiley   +1 more source

Beyond the IFTA – Phase mask generation for 3D laser beam shaping, tailored temperature distributions and optical amplifiers

open access: yesJournal of the European Optical Society-Rapid Publications
The iterative Fourier transform algorithm (IFTA) is the most widely used algorithm for the generation of phase masks for laser beam shaping in the field of laser material processing. But its simplicity and efficiency also come with heavy limitations.
Hofmann Oskar   +4 more
doaj   +1 more source

A Simplified Model for Optical Systems with Random Phase Screens

open access: yesSensors, 2021
A first-order optical system with arbitrary multiple masks placed at arbitrary positions is the basic scheme of various optical systems. Generally, masks in optical systems have a non-shift invariant (SI) effect; thus, the individual effect of each mask ...
Malchiel Haskel, Adrian Stern
doaj   +1 more source

Bifractality of the Devil's staircase appearing in the Burgers equation with Brownian initial velocity

open access: yes, 1996
It is shown that the inverse Lagrangian map for the solution of the Burgers equation (in the inviscid limit) with Brownian initial velocity presents a bifractality (phase transition) similar to that of the Devil's staircase for the standard triadic ...
A. Noullez   +7 more
core   +3 more sources

Phase sensitivity in forward masking [PDF]

open access: yesThe Journal of the Acoustical Society of America, 1981
Forward-masking functions were obtained using sinusoidal maskers of 300-ms duration followed by a 20-ms test signal at the same frequency. Changing the phase of the test signal relative to the phase of the masker leads to variations of the masking threshold of up to 6 dB.
Robert V. Shannon, Christoph Schreiner
openaire   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

open access: yesMolecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz   +15 more
wiley   +1 more source

Phase mask coronagraphy at JPL and Palomar

open access: yesEPJ Web of Conferences, 2011
For the imaging of faint companions, phase mask coronagraphy has the dual advantages of a small inner working angle and high throughput. This paper summarizes our recent work in developing phase masks and in demonstrating their capabilities at JPL.
Serabyn E., Mawet D.
doaj   +1 more source

Phase retrieval from power spectra of masked signals [PDF]

open access: yes, 2013
In diffraction imaging, one is tasked with reconstructing a signal from its power spectrum. To resolve the ambiguity in this inverse problem, one might invoke prior knowledge about the signal, but phase retrieval algorithms in this vein have found ...
Bandeira, Afonso S.   +2 more
core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

Artificial Graphene and Related Photonic Lattices Generated With a Simple Method

open access: yesIEEE Photonics Journal, 2014
We fabricate honeycomb and related photonic lattices in a nonlinear crystal with a simple method that is based on the optical Fourier transformation through an amplitude mask (six-hole aperture) superimposed with a phase mask (three tilted glass plates).
Yuanmei Gao   +3 more
doaj   +1 more source

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