Results 81 to 90 of about 2,767,698 (346)

Crypto-baryonic Dark Matter

open access: yes, 2005
It is proposed that dark matter could consist of compressed collections of atoms (or metallic matter) encapsulated into, for example, 20 cm big pieces of a different phase. The idea is based on the assumption that there exists at least one other phase of
C. D. Froggatt   +8 more
core   +4 more sources

Recent Developments and Challenges of Edge Termination Techniques for Vertical Diamond Schottky Barrier Diodes

open access: yesSensors
Thanks to its excellent material properties, diamond-based power electronic devices have garnered widespread attention. The realization of large-sized (over 2 inches) and high-quality single-crystal diamond wafers has significantly accelerated the ...
Genzhuang Li   +5 more
doaj   +1 more source

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

open access: yesMolecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian   +10 more
wiley   +1 more source

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

open access: yesMolecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern   +7 more
wiley   +1 more source

Quantized surface transport in topological Dirac semimetal films

open access: yesNature Communications, 2019
The recent observation of quantum Hall states in bulk Dirac semimetal Cd3As2 is possibly evolved from topological states. Here, Nishihaya et al. report surface quantum oscillation and its evolution into quantum Hall states in Cd3As2 thin films, where ...
Shinichi Nishihaya   +9 more
doaj   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

open access: yesMolecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici   +8 more
wiley   +1 more source

Quantum Hall states observed in thin films of Dirac semimetal Cd3As2

open access: yesNature Communications, 2017
Despite many achievements in the topological semimetal Cd3As2, the high-quality Cd3As2 films are still rare. Here, Uchida et al. grow high-crystallinity and high-mobility Cd3As2 thin films and observe quantum Hall states dependent on the confinement ...
Masaki Uchida   +11 more
doaj   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

open access: yesMolecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert   +13 more
wiley   +1 more source

Ferromagnetic insulator Cr2Ge2Te6 thin films with perpendicular remanence

open access: yesAPL Materials, 2018
Ferromagnetic van der Waals (vdW) insulators possess robust magnetic order even in a few layers of two-dimensional sheets. The heterostructures of such vdW materials prepared by molecular-beam epitaxy (MBE) are one of the ideal platforms for exploration ...
M. Mogi   +6 more
doaj   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

open access: yesMolecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu   +18 more
wiley   +1 more source

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