Results 121 to 130 of about 1,280,007 (347)

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Flexible digital modulation and coding synthesis for satellite communications [PDF]

An architecture and a hardware prototype of a flexible trellis modem/codec (FTMC) transmitter are presented. The theory of operation is built upon a pragmatic approach to trellis-coded modulation that emphasizes power and spectral efficiency.
Budinger, James, Hoerig, Craig, Tague, John, Vanderaar, Mark   +3 more
core   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Multi-mode single sideband time modulation harmonic adaptive beamforming

Zhongguo Jianchuan Yanjiu
ObjectiveThis study proposes an innovative beamforming method to achieve high-efficiency harmonic adaptive beamforming through multi-mode single sideband time modulation technology.MethodA multi-mode single sideband time modulation module containing ...
Tao YANG, Xiaonan ZHAO, Zhenji LIU, Tingting FAN, Liu YANG, Yu XIA, Jingfeng CHEN   +6 more
doaj   +1 more source

Simultaneous measurement of gas absorption and path length by employing the first harmonic phase angle method in wavelength modulation spectroscopy

, 2020
Chenguang Yang, Liang Mei, Xingping Wang, Hao Deng, Mai Hu, Zhenyu Xu, Bing Chen, Yabai He, Ruifeng Kan   +8 more
openalex   +1 more source

Tunable high-order Bessel-like beam generation based on cross-phase modulation

, 2022
Jinpeng Yuan, Xuewen Wang, Lirong Wang, Liantuan Xiao, Suotang Jia   +4 more
openalex   +1 more source

Near-field phase profile and far-field contrast modulation for micro-lens arrays at the refraction limit [PDF]

, 2020
Maryam Yousefi, Daniel Nečesal, Toralf Scharf, Markus Rossi   +3 more
openalex   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

On linear structure and phase rotation invariant properties of block 2(sup l)-PSK modulation codes [PDF]

Two important structural properties of block 2(l)-ary PSK (phase shift keying) modulation codes, linear structure and phase symmetry, are investigated.
Lin, Shu
core   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source