Results 111 to 120 of about 5,106,399 (296)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Method modulation and demodulation signals with quadrature change angle constituent

Технологія та конструювання в електронній апаратурі, 2006
Analytical expressions have been obtained for phase-frequency manipulation with quadrature phase variation and relative quadrature phase variation. These expressions can also be applied to improve spectral efficiency by modifying the angular component of
A. B. Kokhanov
doaj  

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Multi-mode single sideband time modulation harmonic adaptive beamforming

Zhongguo Jianchuan Yanjiu
ObjectiveThis study proposes an innovative beamforming method to achieve high-efficiency harmonic adaptive beamforming through multi-mode single sideband time modulation technology.MethodA multi-mode single sideband time modulation module containing ...
Tao YANG, Xiaonan ZHAO, Zhenji LIU, Tingting FAN, Liu YANG, Yu XIA, Jingfeng CHEN   +6 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Broadband SAR Imaging Based on Narrowband Dense False Target Jamming

Remote Sensing
To meet the multi-device integration requirements faced by electronic warfare systems in the current environment and to address the problem of conventional jamming-based imaging algorithms being unable to achieve a high range resolution under narrowband ...
Gaogao Liu, Ziyu Huang, Haoran Pan, Qidong Zhang, Jiangbo Zhu   +4 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Modulator-free quadrature amplitude modulation signal synthesis

, 2014
The ability to generate high-speed on-off-keyed telecommunication signals by directly modulating a semiconductor laser’s drive current was one of the most exciting prospective applications of the nascent field of laser technology throughout the 1960s ...
Kelly, Brian, O’Carroll, John, Slavík, Radan, Phelan, Richard, Richardson, David J., Liu, Zhixin, Kakande, Joseph   +6 more
core   +1 more source

Generation of frequency modulated laser pulses in a cylindrical semiconductor structure with a traveling space charge wave

Компьютерная оптика
The propagation of a slow surface electromagnetic wave of the whispering gallery mode type formed on the surface of a semiconductor cylindrical waveguide is considered.
A.S. Abramov, A.S. Kadochkin , S.G. Moiseev, D.G. Sannikov   +3 more
doaj   +1 more source