Results 91 to 100 of about 786,843 (253)

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Phase Modulation Side Channels: Jittery JTAG for On-Chip Voltage Measurements

Transactions on Cryptographic Hardware and Embedded Systems
Measuring fluctuations of the clock phase was identified as a source of leakage in early electromagnetic side-channel investigations. Despite this, only recently was measuring the clock phase (or jitter) of digital signals (not electromagnetic signals ...
Colin O’Flynn
doaj   +1 more source

Large-scale spectral bandwidth compression by complex electro-optic temporal phase modulation

, 2018
Spectral-temporal shaping of quantum light has important applications in quantum communications and photonic quantum information processing. Electro-optic temporal lenses have recently been recognized as a tool for noise-free, efficient spectral ...
Karpinski, Michal, Sosnicki, Filip
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Spectral phase conjugation with cross-phase modulation compensation [PDF]

, 2004
Spectral phase conjugation with short pump pulses in a third-order nonlinear material is analyzed in depth. It is shown that if signal amplification is considered, the conversion efficiency can be significantly higher than previously considered, while ...
Psaltis, Demetri, Tsang, Mankei
core  

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

An extensive photometric study of the Blazhko RR Lyrae star RZ Lyr

, 2012
The analysis of recent, extended multicolour CCD and archive photoelectric, photographic and visual observations has revealed several important properties of RZ Lyr, an RRab-type variable exhibiting large-amplitude Blazhko modulation. On the time-base of
Belucz, B., Dózsa, Á., Fehér, V., Görög, N., Hajdu, G., Jurcsik, J., Kriskovics, L., Kun, E., Kővári, Zs., Molnár, L., Nagy, I., Posztobányi, K., Smitola, P., Szeidl, B., Sódor, Á., Vida, K.   +15 more
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Laser-induced speckle scatter patterns in Bacillus colonies

Frontiers in Microbiology, 2014
Label-free bacterial colony phenotyping technology called BARDOT (BActerial Rapid Detection using Optical scattering Technology) provided successful classification of several different bacteria at the genus, species, and serovar level. Recent experiments
Huisung eKim, Atul K Singh, Arun K Bhunia, Euiwon eBae   +3 more
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source