Results 91 to 100 of about 517,913 (266)

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Broadband SAR Imaging Based on Narrowband Dense False Target Jamming

Remote Sensing
To meet the multi-device integration requirements faced by electronic warfare systems in the current environment and to address the problem of conventional jamming-based imaging algorithms being unable to achieve a high range resolution under narrowband ...
Gaogao Liu, Ziyu Huang, Haoran Pan, Qidong Zhang, Jiangbo Zhu   +4 more
doaj   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Generation of frequency modulated laser pulses in a cylindrical semiconductor structure with a traveling space charge wave

Компьютерная оптика
The propagation of a slow surface electromagnetic wave of the whispering gallery mode type formed on the surface of a semiconductor cylindrical waveguide is considered.
A.S. Abramov, A.S. Kadochkin , S.G. Moiseev, D.G. Sannikov   +3 more
doaj   +1 more source

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

Wide-Range All-Fiber Optical Current Transformer Based on Spatial Non-Reciprocal Phase Modulation

Photonics
A reflective all-fiber optical current transformer based on a spatial non-reciprocal phase modulation technique is investigated by theoretical analysis and experimental measurement.
Tianxiao Zhang, Weibin Feng, Haosong Yang, Yanyan Liu, Yuefeng Qi   +4 more
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Method modulation and demodulation signals with quadrature change angle constituent

Технологія та конструювання в електронній апаратурі, 2006
Analytical expressions have been obtained for phase-frequency manipulation with quadrature phase variation and relative quadrature phase variation. These expressions can also be applied to improve spectral efficiency by modifying the angular component of
A. B. Kokhanov
doaj  

Effects of amplitude modulation and non-linearity in phase modulators on a unidirectional phase modulator

, 2018
A unidirectional phase modulator consisting of two phase modulators is studied experimentally. Analysis of the results shows the importance of non-linear and residual amplitude modulation effects in the modulators.
van Schaijk, T.T.M., Lenstra, D., Williams, K.A., Bente, E.A.J.M.   +3 more
openaire   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source