Results 121 to 130 of about 522,881 (264)

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Reconfigurable magneto-optical diffractive neural network with enhanced optical phase modulation. [PDF]

Sci Rep
Sakaguchi H, Watanabe K, Ikeda J, Sumi S, Awano H, Chafi FZ, Ishibashi T.   +6 more
europepmc   +1 more source

Novel metasurface phase-modulation mechanism. [PDF]

Light Sci Appl, 2021
Song Q.
europepmc   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Analytical investigation of soliton dynamics in the Fokas-Lenells equation with generalized self-phase modulation and nonlinear dispersion. [PDF]

Sci Rep
Rehman HU, Khushi K, Yildirim Y, Allahyani SA, Gusu DM.   +4 more
europepmc   +1 more source

Optical Logic Gates Excited by a Gauss Vortex Interference Beam Based on Spatial Self-Phase Modulation in 2D MoS₂. [PDF]

Nanomaterials (Basel), 2023
Chen X, Ding G, Tang L, Zou H, Wang C, Chen S, Su C, Li Y.   +7 more
europepmc   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Vibrational Energy Harvesting via Phase Modulation: Effects of Different Excitations. [PDF]

Entropy (Basel)
Adesina PO, Vincent UE, Kolebaje OT.
europepmc   +1 more source

Full 2π tunable phase modulation using avoided crossing of resonances. [PDF]

Nat Commun, 2022
Kim JY, Park J, Holdman GR, Heiden JT, Kim S, Brar VW, Jang MS.   +6 more
europepmc   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source