Results 141 to 150 of about 491,257 (266)

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Ultrafast Laser Direct Writing of Diffraction Gratings in PVA/AA Photopolymer with Tunable Phase Modulation Mechanisms. [PDF]

Polymers (Basel)
Bernabeu AP, Bravo JC, Sirvent-Verdú JJ, Nieto-Rodríguez B, Puerto D, Gallego S.   +5 more
europepmc   +1 more source

Programmable and tunable flat-top supercontinuum laser sources via electro-optic intensity and phase modulation scheme. [PDF]

Sci Rep, 2022
Song M, Song M, Lim S, Choi H, Lee T, Choi G, Jung Y, Ahn JT.   +7 more
europepmc   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Interplay of electronic and magnetic phase modulation in a spin-polarised nanomagnet. [PDF]

Sci Rep
Kar S, Gupta N, Roy D, Ray SJ.
europepmc   +1 more source

Giant nonlinear self-phase modulation of large-amplitude spin waves in microscopic YIG waveguides. [PDF]

Sci Rep, 2022
Merbouche H, Divinskiy B, Nikolaev KO, Kaspar C, Pernice WHP, Gouéré D, Lebrun R, Cros V, Ben Youssef J, Bortolotti P, Anane A, Demokritov SO, Demidov VE.   +12 more
europepmc   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

RF phase modulation improves quantitative transient state sequences under constrained conditions. [PDF]

MAGMA
Fuderer M, Liu H, van der Heide O, van den Berg CAT, Sbrizzi A.   +4 more
europepmc   +1 more source

Spin-decoupling of vertical cavity surface-emitting lasers with complete phase modulation using on-chip integrated Jones matrix metasurfaces. [PDF]

Nat Commun, 2022
Ni PN, Fu P, Chen PP, Xu C, Xie YY, Genevet P.   +5 more
europepmc   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source