Results 71 to 80 of about 5,332,729 (289)
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source
FEBS Letters, EarlyView.Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Convergence of phase noise in DPSK transmission systems by novel phase noise averagers
Optics Express, 2006 This investigation proposes a novel all-optical phase noise averager to reduce residual phase noise in the differential phase-shift keying (DPSK) transmission system with phase-preserving amplitude regenerators. The proposed phase noise averager is based on a phase-sensitive amplifier but does not require an extra phase-locking optical pump beam.
Chia Chien, Wei, Jason Jyehong, Chen
openaire +2 more sources
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Design and analysis of high performance low noise oscillators and phase lock loops
, 2010 The design and implementation of high purity, high speed and power efficient clock generation Integrated Circuits continue to be one the greatest challenges facing IC designers today. In order to address this challenge, this thesis considers the modeling
Ke, Li
core +1 more source
, 2013 One hundred years after Luigi Russolo’s “The Art of Noises,” this book exposes a cross-section of the current motivations, activities, thoughts, and reflections of composers, performers, and artists who work with noise in all of its many forms.
Einbond, Aaron, Cassidy, Aaron
core +3 more sources
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Cosmic radio noise absorption events associated with equatorward drifting arcs during a substorm growth phase [PDF]
, 2004 International audienceCosmic radio noise absorption (CNA) events associated with equatorward drifting arcs during a substorm growth phase are studied by using simultaneous optical auroral, IRIS imaging riometer and EISCAT incoherent scatter radar ...
S. R. Marple +7 more
core +2 more sources