Results 131 to 140 of about 11,948,985 (352)

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Beyond the Phase Ordering Problem: Finding the Globally Optimal Code w.r.t. Optimization Phases

CoRR
In this paper, we propose a new concept called \textit{semantically equivalence} \wrt \textit{optimization phases} \textit{(\sep)}, which defines the set of programs a compiler considers semantically equivalent to the input using a set of optimization phases.
Yu Wang, Hongyu Chen, Ke Wang 0022
openaire   +2 more sources

Optimal Designs of Two-Phase Studies

Journal of the American Statistical Association, 2019
The two-phase design is a cost-effective sampling strategy to evaluate the effects of covariates on an outcome when certain covariates are too expensive to be measured on all study subjects. Under such a design, the outcome and inexpensive covariates are measured on all subjects in the first phase and the first-phase information is used to select ...
Ran, Tao, Donglin, Zeng, Dan-Yu, Lin
openaire   +3 more sources

Double Closed-Loop PI Control of Three-Phase Inverters by Binary-Coded Extremal Optimization

IEEE Access, 2016
How to design an effective and efficient double closed-loop proportional-integral (PI) controller for a three-phase inverter to obtain satisfied quality of output voltage waveform is of great practical significance.
Yu-Xing Dai, Huan Wang, Guo-Qiang Zeng
doaj   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Using mHealth to promote parents' brushing of preschool children's teeth: a protocol for a randomized factorial trial using the Multi-phase Optimization Strategy (MOST). [PDF]

Trials, 2022
Ihab M, El Din WE, Ammar N, Yassin R, El Tantawi M.   +4 more
europepmc   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Comparison of Evolutionary Optimization Algorithms for FM-TV Broadcasting Antenna Array Null Filling

, 2015
Broadcasting antenna array null filling is a very challenging problem for antenna design optimization. This paper compares five antenna design optimization algorithms (Differential Evolution, Particle Swarm, Taguchi, Invasive Weed, Adaptive Invasive ...
Bruce, Mehrdadi, Aristotelis, Bizopoulos, Emmanouil, Tziris, Zaharias, Zaharis, John, Cosmas, Ian, Glover, Violeta, Holmes, Pavlos, Lazaridis   +7 more
core  

A hierarchical time-varying optimization algorithm for Photovoltaic-energy storage to suppress three-phase imbalances in active distribution networks

International Journal of Electrical Power & Energy Systems
For three-phase unbalance problems due to excessive single-phase loads, unbalanced load connections and ground faults, etc. This paper proposes a hierarchical time-varying optimization algorithm for active distribution networks to suppress three-phase ...
Xingxu Zhu, Jiyu Wang, Haozheng Yu, Jie Ma, Junhui Li, Cuiping Li   +5 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source