Results 111 to 120 of about 11,948,985 (352)

Phase Transition in Ant Colony Optimization

Physics
Ant colony optimization (ACO) is a stochastic optimization algorithm inspired by the foraging behavior of ants. We investigate a simplified computational model of ACO, wherein ants sequentially engage in binary decision-making tasks, leaving pheromone ...
Shintaro Mori, Shogo Nakamura, Kazuaki Nakayama, Masato Hisakado   +3 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Optimization of functionally gradient materials in valve design under cyclic thermal and mechanical loading

Computer Assisted Methods in Engineering and Science, 2017
The robust and simple optimization method of functionally graded material (FGM) for combined cyclic thermal and mechanical loading with application to valve design is proposed.
Grzegorz Maciejewski, Zenon Mróz
doaj   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

A Novel Diversity Guided Galactic Swarm Optimization With Feedback Mechanism

IEEE Access
Galactic Swarm Optimization (GSO) is an optimization method inspired by the movements of stars and star clusters in the galaxy. This method aims to find the best solution in two phases using other known optimization methods.
Oguzhan Uymaz, Bahaeddin Turkoglu, Ersin Kaya, Tunc Asuroglu   +3 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Phase-field topology optimization with periodic microstructure

Progress in additive manufacturing technologies allows the realization of finely graded microstructured materials with tunable mechanical properties.
Ulisse Stefanelli, Stefano Almi
core   +1 more source

A Phase Correction Model for Fourier Transform Spectroscopy

Applied Sciences
In Fourier transform spectroscopy (FTS), the conventional Mertz method is commonly used to correct phase errors of recovered spectra, but it performs poorly in correcting nonlinear phase errors.
Huishi Cheng, Honghai Shen, Lingtong Meng, Chenzhao Ben, Ping Jia   +4 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Study on Particle Swarm Optimization Variant and Simulated Annealing in Vapor Liquid Equilibrium Calculation

Reaktor, 2019
Phase equilibrium calculation plays a major rule in optimization of separation process in chemical processing. Phase equilibrium calculation is still very challenging due to highly nonlinear and non-convex of mathematical models.
Rama Oktavian, Agung Ari Wibowo, Zuraidah Fitriah   +2 more
doaj   +1 more source